Updated statistics with estimated new cases and deaths for 2018. Also revised text to state that from 2005 to 2014, the incidence rate increased by 3% per year among adults aged 50 years and older; however, data from the same period indicate that incidence rates stabilized in individuals younger than 50 years; in addition, from 2006 to 2015, mortality rates declined by 1% per year in individuals aged 50 years and older and declined by 2.6% per year in individuals younger than 50 years.
Added text to state that observer variability among physicians has been noted in the evaluation of skin lesions and subsequent biopsy specimens.
Added text about a study of 187 pathologists who practiced in the United States that found that cases of moderately dysplastic nevi to early-state invasive melanoma had less than 50% agreement, with a reference diagnosis defined by consensus of experienced pathologists; at a U.S. population level, it is estimated that 82.8% of melanocytic skin biopsy diagnoses would be verified if they were reviewed by a consensus reference panel of experienced pathologists (cited Elmore et al. as reference 19). Also added text to state that differentiating between benign and malignant melanocytic tumors during histologic examinations of biopsy specimens has been shown to be inconsistent, even in the hands of experienced dermatopathologists; this variability in the diagnosis of melanocytic lesions undermines the results of studies that examine screening effectiveness and also may undermine the effectiveness of any screening intervention, suggesting that requesting a second opinion regarding the pathology of biopsy specimens may be important (cited Farmer et al. as reference 20 and Lott et al. as reference 21).
ver historia personal en: www.cerasale.com.ar [dado de baja por la Cancillería Argentina por temas políticos, propio de la censura que rige en nuestro medio]//
weblog.maimonides.edu/farmacia/archives/UM_Informe_Autoevaluacion_FyB.pdf - //
weblog.maimonides.edu/farmacia/archives/0216_Admin_FarmEcon.pdf - //
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