Current Highlight from March 3, 2017
Sex and Age Differences in miRNA Expression in Rat Liver
NCTR scientists have shown that a set of 214 miRNAs exhibited differential expression in the liver of untreated rats based on age and/or sex. Of the 214 miRNAs, 212 showed age-related differences while 65 showed sex-related differences. In general, miRNA expression was largely stable between sexes and across the rat life span, with notable exception of 38 miRNAs at 2 weeks of age, which is consistent with early developmental proliferation and differentiation. As rats mature from adults to old age, miRNAs involved in cell death, cell proliferation, and cell cycle were found to change expression. The results of this study will improve our understanding of epigenetic regulation of hepatic gene expression. Furthermore these miRNA changes may be a factor in observing differences in age- and sex-dependent susceptibilities to toxicity. This study is available online at Biology of Sex Differences
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NCTR scientists have shown that a set of 214 miRNAs exhibited differential expression in the liver of untreated rats based on age and/or sex. Of the 214 miRNAs, 212 showed age-related differences while 65 showed sex-related differences. In general, miRNA expression was largely stable between sexes and across the rat life span, with notable exception of 38 miRNAs at 2 weeks of age, which is consistent with early developmental proliferation and differentiation. As rats mature from adults to old age, miRNAs involved in cell death, cell proliferation, and cell cycle were found to change expression. The results of this study will improve our understanding of epigenetic regulation of hepatic gene expression. Furthermore these miRNA changes may be a factor in observing differences in age- and sex-dependent susceptibilities to toxicity. This study is available online at Biology of Sex Differences
.
For more information, please contact James Fuscoe, Ph.D., Branch Director, Personalized Medicine Branch, Division of Systems Biology, FDA/NCTR.
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