Tumor angiogenesis
Tumor Angiogenesis
Forming efficient vasculature network, also known as tumor angiogenesis, is a critical hallmark in tumor development. Explorations on its underlying molecular mechanisms have resulted in several novel anti-cancer drugs approved by the Food & Drug Administration (FDA) of the United States. However, the modest survival benefits from anti-angiogenic therapy have forced us to revisit our understanding on tumor angiogenesis. In this special issue of the Chinese Journal of Cancer (CJC), the world leading experts in pathology, molecular biology, pharmacology, and clinical study have contributed their critical thoughts and insightful investigations from different angles to reveal the alternative tumor angiogenesis approaches and potential treatment targets. This special issue is therefore initiating a new era in tumor angiogenesis research, aiming to develop next-generation anti-angiogenic targeted therapy.
Edited by Francesco Pezzella and Chao-Nan Qian
- REVIEW
Combination therapy in cancer: effects of angiogenesis inhibitors on drug pharmacokinetics and pharmacodynamics
Validated preclinical studies have provided evidence that anti-vascular endothelial growth factor (VEGF) compounds enhance the activity of subsequent antitumor therapy, but the mechanism of this potentiation i...Chinese Journal of Cancer 2016 35:61Published on: 29 June 2016 - EDITORIAL
Twenty years after: the beautiful hypothesis and the ugly facts
The limited clinical benefits from current antiangiogenic therapy for cancer patients have triggered some critical thoughts and insightful investigations aiming to further elucidate the relationship between ve...Chinese Journal of Cancer 2016 35:22Published on: 24 February 2016 - REVIEW
Future options of anti-angiogenic cancer therapy
In human patients, drugs that block tumor vessel growth are widely used to treat a variety of cancer types. Many rigorous phase 3 clinical trials have demonstrated significant survival benefits; however, the a...Chinese Journal of Cancer 2016 35:21Published on: 15 February 2016 - REVIEW
Mechanisms of vascularization in murine models of primary and metastatic tumor growth
Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; in...Chinese Journal of Cancer 2016 35:19Published on: 12 February 2016 - ORIGINAL ARTICLE
Why some tumours trigger neovascularisation and others don’t: the story thus far
Angiogenesis is not essential for tumours to develop and expand, as cancer can also grow in a non-angiogenic fashion, but why this type of growth occurs is unknown. Surprisingly, our data from mRNA transcripti...Chinese Journal of Cancer 2016 35:18Published on: 12 February 2016 - ORIGINAL ARTICLE
Comparisons of biophysical properties and bioactivities of mono-PEGylated endostatin and an endostatin analog
Endostatin (ES) is a well-established potent endogenous antiangiogenic factor. An ES variant, called zinc-binding protein-ES (ZBP-ES), is clinically available; however, its use is limited by rapid renal cleara...Chinese Journal of Cancer 2016 35:14Published on: 20 January 2016 - REVIEW
Revisiting tumor angiogenesis: vessel co-option, vessel remodeling, and cancer cell-derived vasculature formation
Tumor growth and metastasis depend on the establishment of tumor vasculature to provide oxygen, nutrients, and other essential factors. The well-known vascular endothelial growth factor (VEGF) signaling is cru...Chinese Journal of Cancer 2016 35:10Published on: 8 January 2016
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