First author Andrea Marzi, Ph.D., of NIAID's Laboratory of Virology, is shown in August 2014 analyzing Ebola test results from the ELWA3 hospital compound in Monrovia, Liberia.
Credit: NIAID
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Single Dose Ebola Vaccine: Safe, Effective in Monkeys against Outbreak Strain
NIH scientists report that a single dose of an experimental Ebola virus vaccine completely protects monkeys against the current outbreak strain, EBOV-Makona, when given at least seven days before exposure, and partially protects them if given three days prior. The vaccine, VSV-EBOV, uses genetically engineered vesicular stomatitis virus to carry an EBOV gene that safely induces protective immunity. The experimental vaccine is currently undergoing testing in a global clinical trial in humans.
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