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Virology Journal 2015, 12:120HCV in HIV-positive men who have sex with menMolecular characterization of HCV in HIV-positive men who have sex with men demonstrated that the origin of HCV in this population was diverse and not directly linked with local injection drug users.
Genome Medicine 2015, 7:87Ovarian cancer landscapeExome sequencing of mucinous ovarian carcinoma tumors reveals multiple mutational targets, suggesting tumors arise through many routes, and shows this group of tumors is distinct from other subtypes.
Genome Biology 2015, 16:158BioWardrobeA platform allowing users to store, visualize and analyze epigenomics and transcriptomics data using a biologist-friendly web interface, without the need for programming expertise.
BMC Medicine 2015, 13:184Are RAS-positive thyroid nodules malignant?In patients with thyroid nodules, RAS oncogene mutations are associated with malignancy risk, but the majority of RAS-positive cancers are low-risk, suggesting that RAS expression should not be used alone to guide clinical decision-making.
Genome Biology 2015, 16:152Bipartite structure of the inactive mouse X chromosomeThe active and inactive X chromosomes have different three dimensional structures, with the inactive X being similar in mouse and human
Breast Cancer Research 2015, 17:103Alcohol and breast cancer riskA study of 25–35-year-old women finds a link between alcohol consumption and increased mammographic density and estrogen levels.
BMC Medicine 2015, 13:182Epigenetic changes associated with PDRAltered blood DNA methylation patterns occur in type 1 diabetes (T1D) patients with proliferative diabetic retinopathy (PDR) compared with those with T1D and no retinopathy, suggesting that epigenetic changes may predict PDR development.
Genome Biology 2015, 16:157OrthoFinderSolving fundamental biases in whole genome comparisons dramatically improves accuracy of orthogroup inference
BMC Medicine 2015, 13:183Does exposure predict malaria episodes?Modeling exposure fails to account for all excess malaria episodes in children living in P. falciparum endemic areas, suggesting additional factors may contribute to unexpected episodes and urging the need for a framework to identify those at risk.
Breast Cancer Research 2015, 17:102Metastasis or second primary?Whole genome sequencing was used to differentiate metastatic from second primary tumors in contralateral breast cancer patients: a distinction with clinical implications for treatment and prognosis.
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