Current Highlight from May 29, 2015
Quantitative Analysis of the Relative Mutagenicity of Tobacco Smoke Constituents
To develop tools for using genotoxicity data to quantitatively evaluate the risk of tobacco products, NCTR and CTP scientists developed a mouse lymphoma assay (MLA) model to test the mutagenicity of five chemical constituents found in cigarette smoke (4-ABP, BaP, cadmium chloride, MelQ, and NNK). The study included the evaluation of various quantitative approaches for analyzing the resulting mutagenicity data. The results suggest that the MLA model is capable of discriminating the mutagenicity of various tobacco smoke constituents and that quantitative analyses are available that can be useful in distinguishing between the exposure responses. A manuscript detailing the results of the study is available online at Mutagenesis
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.For additional information, please contact Nan Mei, Staff Fellow, Division of Genetic and Molecular Toxicology, FDA/NCTR.
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