Detection of Circovirus in Foxes with Meningoencephalitis, United Kingdom, 2009–2013 - Volume 21, Number 7—July 2015 - Emerging Infectious Disease journal - CDC
Volume 21, Number 7—July 2015
Detection of Circovirus in Foxes with Meningoencephalitis, United Kingdom, 2009–2013
Circoviruses (family Circoviridae) are nonenveloped, single-stranded, circular DNA (≈2 kb) viruses (1). Two genera, Circovirus and Gyrovirus, are recognized, and an additional genus, Cyclovirus, has been proposed (1,2). Circoviruses have an ambisense genome organization with 2 major inversely arranged open reading frames encoding the rolling circle replication initiator protein gene (Rep) and a capsid protein gene (Cap) (1). A conserved stem–loop structure, required for viral replication, is located between the 5′ ends of the 2 main open reading frames. Circoviruses are thought to exhibit host species specificity and have been detected in various species, including birds, pigs, and dogs (1,3,4). These viruses have been associated with a variety of diseases, including respiratory and enteric disease, dermatitis, and reproductive problems (1,3–5). Recently, many small circular DNA genomes have been described from different hosts by using different methods, including high-throughput sequencing (6). Here we describe the identification, characterization, and prevalence of a newly discovered fox circovirus that was present in serum and brain samples from foxes with unexplained meningoencephalitis in the United Kingdom.
Mr. Bexton is the senior veterinarian at the RSPCA Norfolk Wildlife Hospital, East Winch, United Kingdom. His main research interests are the epidemiology and pathology of wildlife diseases including novel pathogens in free-living animals.
This work was partially funded by the European Commission’s COMPARE H2020 project under grant agreement No 643476, the Virgo Consortium, and ZonMW TOP project 91213058.
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Suggested citation for this article: Bexton S, Wiersma LC, Getu S, van Run PR, Verjans GM, Schipper D, et al. Detection of circovirus in foxes with meningoencephalitis, United Kingdom. Emerg Infect Dis. 2015 Jul [date cited]. http://dx.doi.org/10.3201/eid2107.150228