jueves, 4 de junio de 2015

CYB5R3 - cytochrome b5 reductase 3 - Genetics Home Reference

CYB5R3 - cytochrome b5 reductase 3 - Genetics Home Reference

Genetics Home Reference: your guide to understanding genetic conditions


What is the official name of the CYB5R3 gene?

The official name of this gene is “cytochrome b5 reductase 3.”
CYB5R3 is the gene's official symbol. The CYB5R3 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.

What is the normal function of the CYB5R3 gene?

The CYB5R3 gene provides instruction for making an enzyme called cytochrome b5 reductase 3. This enzyme is involved in transferring negatively charged particles called electrons from one molecule to another. Two versions (isoforms) of this enzyme are produced from the CYB5R3 gene. The soluble isoform is present only in red blood cells, and the membrane-bound isoform is found in all other cell types.
Normal red blood cells contain molecules of iron-containing hemoglobin, which deliver oxygen to the body's tissues. The iron in hemoglobin is ferrous (Fe2+), but it can spontaneously become ferric (Fe3+). Hemoglobin that contains ferric iron is called methemoglobin, and it cannot deliver oxygen. The soluble isoform of cytochrome b5 reductase 3 changes ferric iron back to ferrous iron so hemoglobin can function. Normally, red blood cells contain less than 2 percent methemoglobin.
The membrane-bound isoform is embedded in the membranes of various cellular compartments and is widely used in the body. This isoform is necessary for many chemical reactions, including the breakdown and formation of fatty acids, the formation of cholesterol, and the breakdown of various molecules and drugs.

How are changes in the CYB5R3 gene related to health conditions?

autosomal recessive congenital methemoglobinemia - caused by mutations in the CYB5R3 gene
More than 65 mutations in the CYB5R3 gene have been found to cause autosomal recessive congenital methemoglobinemia types I and II. Most of these CYB5R3 gene mutations cause autosomal recessive congenital methemoglobinemia type I, which is characterized by a lack of oxygen in the body's tissues and bluish appearance of the skin, lips, and nails (cyanosis). The mutations that cause type I usually reduce enzyme activity or stability. As a result, the enzyme cannot efficiently change ferric iron to ferrous iron, leading to a 10 to 50 percent increase in methemoglobin within red blood cells. This increase in methemoglobin and corresponding decrease in normal hemoglobin reduces the amount of oxygen delivered to tissues. The altered enzyme activity affects only red blood cells because other cells can compensate for a decrease in enzyme activity, but red blood cells cannot.
The CYB5R3 gene mutations that cause autosomal recessive congenital methemoglobinemia type II result in the more severe form of the two types. In addition to cyanosis, people with this form have neurological problems. The mutations that cause type II typically result in a complete loss of enzyme activity. Cells cannot compensate for a complete loss of cytochrome b5 reductase 3, which results in a 10 to 70 percent increase in methemoglobin within red blood cells. This increase in methemoglobin and corresponding decrease in normal hemoglobin leads to cyanosis. The lack of enzyme activity in other cells leads to the neurological features associated with type II. Researchers suspect that the neurological problems are caused by impaired fatty acid and cholesterol formation, which reduces the production of a fatty substance called myelin. Myelin insulates nerve cells and promotes the rapid transmission of nerve impulses. This reduced ability to form myelin (hypomyelination) leads to a loss of nerve cells, particularly in the brain. The loss of these cells likely contributes to the encephalopathy and movement disorders characteristic of autosomal recessive congenital methemoglobinemia type II.
other disorders - associated with the CYB5R3 gene
A normal variant (polymorphism) in the CYB5R3 gene has been associated with low methemoglobin levels in infants who were born prematurely and treated with nitric oxide to prevent chronic lung disease. The lungs of premature infants are often underdeveloped and need support after birth. Nitric oxide widens the blood vessels of the lungs, allowing for more oxygen to get to the blood flowing through the vessels of the lungs. However, nitric oxide attaches (binds) to hemoglobin in red blood cells, which converts the hemoglobin into methemoglobin. If too much nitric oxide is administered to premature infants, more hemoglobin is turned into methemoglobin, and red blood cells cannot carry enough oxygen to the body's cells and tissues. This complication is known as methemoglobin toxicity. The polymorphism associated with low methemoglobin levels replaces the DNA building block (nucleotide) guanine with the nucleotide adenine at a specific place in the CYB5R3 gene (written as 9015G>A). As a result, cytochrome b5 reductase 3 activity is increased, leading to an increased ability to convert methemoglobin back to hemoglobin, a rise in oxygen delivery, and a reduced risk of methemoglobin toxicity.
Another polymorphism in the CYB5R3 gene has been found to increase the risk of breast cancer in African American women who smoke cigarettes. Cigarette smoke contains chemicals that can cause errors in DNA. These errors prevent cells from controlling their own growth and division, which can lead to the formation of a cancerous tumor. Normally, the cytochrome b5 reductase 3 enzyme can break down these chemicals into nontoxic substances, specifically targeting chemicals that have been shown to be involved in breast cancer. However, women who have a specific CYB5R3 gene polymorphism that changes the way the gene's instructions are used to make the protein (written as I1M+6C>T) have reduced enzyme activity. As a result, the chemicals from cigarette smoke are not broken down. They cause errors in DNA that allow cells to grow without control or order, leading to breast cancer. Studies show that the CYB5R3gene polymorphism associated with breast cancer occurs at a 90-fold higher rate in African-American women than in white women.

Where is the CYB5R3 gene located?

Cytogenetic Location: 22q13.2
Molecular Location on chromosome 22: base pairs 42,617,839 to 42,649,398
The CYB5R3 gene is located on the long (q) arm of chromosome 22 at position 13.2.
The CYB5R3 gene is located on the long (q) arm of chromosome 22 at position 13.2.
More precisely, the CYB5R3 gene is located from base pair 42,617,839 to base pair 42,649,398 on chromosome 22.

Where can I find additional information about CYB5R3?

You and your healthcare professional may find the following resources about CYB5R3 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the CYB5R3 gene or gene products?

  • B5R
  • DIA1
  • diaphorase-1
  • NADH-cytochrome b5 reductase 3
  • NADH-diaphorase 1

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding CYB5R3?

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
References (9 links)

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook

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