Rheumatoid Arthritis Genomics: Severity & Treatment Response - April 29, 2015

Genomics|Features|Rheumatoid Arthritis

Rheumatoid Arthritis

Rheumatoid Arthritis Genomics: Severity & Treatment Response - April 29, 2015

CDC and Related Info

• Rheumatoid arthritis
• Genes reported in relation to arthritis, including genomewide association studies via theHuGE Navigator

Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response 

Viatte S et al. JAMA, April 28, 2015

RA treatment response influenced by HLA-DRB1 haplotype by JC Kelly, Medscape, Apr 28 [by free subscription only]

Genetic architectures of seropositive and seronegative rheumatic diseases.

Kirino Y et al. Nat Rev Rheumatol 2015 Apr 28.

Human leukocyte antigen polymorphisms and personalized medicine for rheumatoid arthritis.

Furukawa H et al. J. Hum. Genet. 2015 Apr 23.

Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis.

Ferreiro-Iglesias A et al. Pharmacogenomics J. 2015 Apr 21.

A genome-wide association study identifies a new locus associated with the response to anti-TNF therapy in rheumatoid arthritis.

Julià A et al. Pharmacogenomics J. 2015 Apr 21.

Genetic variants within the TNFRSF1B gene and susceptibility to rheumatoid arthritis and response to anti-TNF drugs: a multicenter study.

Canet LM et al. Pharmacogenet. Genomics 2015 Apr 4.

Variation at FCGR2A and functionally related genes is associated with the response to anti-TNF therapy in rheumatoid arthritis.

Avila-Pedretti G et al. PLoS ONE 2015 (4) e0122088

FcGR genetic polymorphisms and the response to adalimumab in patients with rheumatoid arthritis.

Dávila-Fajardo CL et al. Pharmacogenomics 2015 Mar (4) 373-81

Genetic contribution of DKK-1 polymorphisms to RA structural severity and DKK-1 level of expression.

Miceli-Richard C et al. Ann. Rheum. Dis. 2015 Mar 24.

Rheumatoid Arthritis: Recent Genetic Insights - February 5, 2015

To what extent is the familial risk of rheumatoid arthritis explained by established rheumatoid arthritis risk factors?

Jiang Xia et al. Arthritis & rheumatology (Hoboken, N.J.) 2015 Feb (2) 352-62

Heritability of RA remains unexplained. Established risk factors only provide partial explanation for familial risk of rheumatoid arthritis

by Pam Harrison, Medpage Today, Feb 5

Personalized medicine in rheumatoid arthritis: is the glass half full or half empty.

Huizinga TW. J Intern Med. 2014 Oct 14.

The genetics of rheumatoid arthritis: risk and protection in different stages of the evolution of RA.

Yarwood A, et al. Rheumatology (Oxford). 2014 Sep 18

Association of susceptible genetic markers and autoantibodies in rheumatoid arthritis.

Mohan VK, et al.  J Genet. 2014 Aug;93(2):597-605

Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications.

Magyari L, et al.  World J Orthop. 2014 Sep 18;5(4):516-36.

Genetic basis of rheumatoid arthritis: A current review.

Kochi Y, et al. Biochem Biophys Res Commun. 2014 Sep 19;452(2):254-262.

Early predictors of prognosis in juvenile idiopathic arthritis: a systematic literature review.

van Dijkhuizen EH, et al. Ann Rheum Dis. 2014 Jun 24.

Rheumatoid Arthritis: Genetics and Public Health - October 2, 2014

CDC information: Rheumatoid arthritis

Genetics and rheumatoid arthritis, from the NIH Genetics Home Reference

Check out genetic conditions and tests associated with rheumatoid arthritis, from the NIH Genetic Testing Registry

Did you know? 861 genes have been reported in relation to rheumatoid arthritis risk and outcomes, including 79 genomewide association studies. To find out more, visit the HuGE Navigator

Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans.

Jiang L et al. Arthritis Rheumatol. 2014 May;66(5):1121-32.

RADB: a database of rheumatoid arthritis-related polymorphisms

Zhang R, et al. Database (Oxford) 2014;2014