Hepatitis: Pharmacogenomic Insights - May 4, 2015

Genomics|Features|Hepatitis

Hepatitis

Hepatitis: Pharmacogenomic Insights - May 4, 2015

CDC and Related Info

• Using advanced molecular techniques for rapid identification of hepatitis C outbreaks
• World Hepatitis Day
• CDC information on viral hepatitis
• Take this 5 minute hepatitis risk assessment
• Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945–1965
• Genes reported in relation to hepatitis, including genomewide association studies via theHuGE Navigator

Interleukin 28B polymorphisms as predictors of sustained virological response in chronic hepatitis C: systematic review and meta-analysis.
Cariani E et al.Pharmacogenomics J. 2015 Apr 28.

Intracellular accumulation of boceprevir according to plasma concentrations and pharmacogenetics.
Cusato J et al. Int. J. Antimicrob. Agents 2015 Mar 14.

Serum interferon-related microRNAs as biomarkers to predict the response to interferon therapy in chronic hepatitis C genotype 4.
Motawi TK et al. PLoS ONE 2015 (3) e0120794

PEG-Interferon-a ribavirin-induced HCV viral clearance: a pharmacogenetic multicenter Spanish study.
Milara J et al. Farm Hosp 2015 Jan-Feb (1) 29-43

The role of pharmacogenetics in the treatment of chronic hepatitis C infection.
Kawaguchi-Suzuki M et al. Pharmacotherapy 2014 Feb (2) 185-201

CDC lists pharmacogenomic testing in treatment of hepatitis as tier 2

Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for IFNL3 (IL28B) genotype and PEG interferon-a-based regimens.
Muir AJ et al. Clin. Pharmacol. Ther. 2014 Feb (2) 141-6

Hepatitis: Recent Genomic Insights - February 9, 2015

CDC information: Using advanced molecular techniques for rapid identification of hepatitis C outbreaks

CDC paper: Outbreak of hepatitis A in the USA associated with frozen pomegranate arils imported from Turkey: an epidemiological case study
Collier MG, et al. Lancet Infect Dis. 2014 Sep 3. pii: S1473-3099(14)70883-7.

CDC paper: Next-generation sequencing reveals large connected networks of intra-host HCV variants
Campo DS, et al. BMC Genomics. 2014 Jul 14;15 Suppl 5:S4.

Ultradeep pyrosequencing of NS3 to predict response to triple therapy with protease inhibitors in previously treated chronic hepatitis C patients.
Larrat S et al.  J Clin Microbiol. 2015 Feb;53(2):389-97.

Differentiation of acute from chronic hepatitis C virus infection by NS5B deep sequencing: A population-level tool for incidence estimation.
Montoya V et al. Hepatology. 2015 Feb 2.

Whole genome characterization of hepatitis B virus quasispecies with massively parallel pyrosequencing.
Li F, et al.  Clin Microbiol Infect. 2014 Oct 29

Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota.
Chou HH, et al. Proc Natl Acad Sci U S A. 2015 Feb 2

Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity.
Fujimoto A, et al. Nat Commun. 2015 Jan 30;6:6120

A deep-sequencing method detects drug-resistant mutations in the hepatitis B virus in Indonesians.
Widasari DI, et al. Intervirology. 2014;57(6):384-92.

Cost-effectiveness of IL28Β genotype-guided protease inhibitor triple therapy versus standard of care treatment in patients with hepatitis C genotypes 2 or 3 infection.
Bock JA, et al. Public Health Genomics. 2014;17(5-6):306-19.

A genomic and clinical prognostic index for hepatitis C-related early-stage cirrhosis that predicts clinical deterioration.
King LY, et al. Gut. 2014 Aug 20.

Hepatitis C virus in the new era: perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy.
Ansaldi F, et al. World J Gastroenterol. 2014 Aug 7;20(29):9633-52.

Deep sequencing: becoming a critical tool in clinical virology.
Quiñones-Mateu ME, et al. J Clin Virol. 2014 Sep;61(1):9-19

Hepatitis: Genomics & Public Health - July 31, 2014

CDC information: World Hepatitis Day

CDC information on hepatitis
Hepatitis B and Hepatitis C can become chronic, life-long infections which can lead to liver cancer. Millions of Americans are living with chronic viral hepatitis, and many do not know they are infected

Take this 5 minute hepatitis risk assessment developed by the CDC and get a personalized report

CDC recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945–1965

CDC recommends that an FDA-approved hepatitis C nucleic acid test should be used to identify active hepatitis C infection among persons who test anti-HCV positive

CDC paper: Viral hepatitis C gets personal--the value of human genomics to public health.
Zhang L, Gwinn M, Hu DJ. Public Health Genomics. 2013;16(4):192-7.

Did you know? > 1300 genes have been reported in relation to risk and outcomes of hepatitis, including 56 genomewide association studies and 70 meta analyses? To find out more, visit the HuGE Navigator

Integrative functional genomics of hepatitis C virus infection identifies host dependencies in complete viral replication cycle
Qisheng Li et al. PloS Pathogens, May, 2014

Meta-analysis: implications of interleukin-28B polymorphisms in spontaneous and treatment-related clearance for patients with hepatitis C
María A Jiménez-Sousa et al. BMC Medicine 2013