Full genomic characterization and phylogenetic analysis of a zoonotic human G8P[14] rotavirus strain detected in a sample from guatemala. - PubMed - NCBI

Full genomic characterization and phylogenetic analysis of a zoonotic human G8P[14] rotavirus strain detected in a sample from guatemala. - PubMed - NCBI

Infect Genet Evol. 2015 May 5. pii: S1567-1348(15)00166-5. doi: 10.1016/j.meegid.2015.05.004. [Epub ahead of print]

Full genomic characterization and phylogenetic analysis of a zoonotic human G8P[14] rotavirus strain detected in a sample from guatemala.

Gautam R1, Mijatovic-Rustempasic S2, Roy S2, Esona MD2, Lopez B3, Mencos Y4, Rey-Benito G5, Bowen MD2.

Author information

Abstract

We report the genomic characterization of a rare human G8P[14] rotavirus strain, identified in a stool sample from Guatemala (GTM) during routine rotavirus surveillance. This strain was designated as RVA/Human-wt/GTM/2009726790/2009/G8P[14], with a genomic constellation of G8-P[14]-I2-R2-C2-M2-A13-N2-T6-E2-H3. The VP4 gene occupied lineage VII within the P[14] genotype. Phylogenetic analysis of each genome segment revealed close relatedness to several zoonotic simian, guanaco and bovine strains. Our findings suggest that strain RVA/Human-wt/GTM/2009726790/2009/G8P[14] is an example of a direct zoonotic transmission event. The results of this study reinforce the potential role of interspecies transmission and reassortment in generating novel and rare rotavirus strains which infect humans.

Copyright © 2015. Published by Elsevier B.V.

KEYWORDS:

G8P[14]; Interspecies transmission; Reassortant; Rotavirus

PMID:

 

25952569

 

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