Colorectal Cancer: Public Health and Genomic Insights - May 18, 2015

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Colorectal Cancer

Colorectal Cancer: Public Health and Genomic Insights - May 18, 2015

CDC Info

• Check out the CDC evidence table on tiered classification of genomic tests for colorectal cancer
• Genetic testing for hereditary colorectal cancer
• March is Colorectal Cancer Awareness
• Screen for Life: National Colorectal Cancer Action Campaign
• Colorectal Cancer Awareness
• Listen to a CDC podcast about genetic testing for Lynch syndrome
• Colorectal cancer screening tests

Special Supplement: Colorectal cancer is the world?s fourth most deadly cancer, killing almost 700,000 people every year
Nature Outlook, May 2015

Colorectal cancer: 5 big questions
Chadkrahar S , Nature Outlook, May 2015

Prevention: Tending the gut
Gravitz L , Nature Outlook, May 2015

Screening: Early alert
Willyard C , Nature Outlook, May 2015

Microbiome: Microbial mystery
DeWeerdt S , Nature Outlook, May 2015

A subset of genetic susceptibility variants for colorectal cancer also has prognostic value.
Noci S et al. Pharmacogenomics J. 2015 May 12.

Variations in genes involved in dormancy associated with outcome in patients with resected colorectal liver metastases.
Stremitzer S et al. Ann. Oncol. 2015 May 8.

A colorectal cancer prediction model using traditional and genetic risk scores in Koreans.
Jung Keum Ji et al. BMC Genet. 2015 (1) 49

Association between polymorphisms in vascular endothelial growth factor gene and response to chemotherapies in colorectal cancer: A meta-analysis.
Wang L et al. PLoS ONE 2015 (5) e0126619

Familial colorectal cancer.
Lung MS et al. Intern Med J 2015 May (5) 482-91

Next-generation sequencing panels for the diagnosis of colorectal cancer and polyposis syndromes: A cost-effectiveness analysis.
Gallego CJ et al. J. Clin. Oncol. 2015 May 4.

Genetic polymorphisms in cytochrome P450 and clinical outcomes of FOLFIRI chemotherapy in patients with metastatic colorectal cancer.
Dong N et al. Tumour Biol. 2015 May 2.

Screening in GI cancers: The role of genetics.
Stoffel EM et al. J. Clin. Oncol. 2015 Apr 27.

Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk.
Baert-Desurmont S et al. Eur. J. Hum. Genet. 2015 Apr 15. 

Genomic Tests in Management of Colorectal Cancer - April 2, 2015

Costs and effectiveness of genomic testing in the management of colorectal cancer.
Goldstein DA et al. Oncology (Williston Park, N.Y.) 2015 Mar 15. (3)

ASCP/CAP/AMP/ASCO evaluation of molecular markers for colorectal cancer draft recommendations

Genomic testing in colorectal cancer: How much is enough? 
Dienstmann R et al, Oncology, March 2015

Cost-effectiveness of genomic testing for colorectal cancer: Are we there yet?
Barzi A et al. Oncology, March 2015

Check out the CDC evidence table on tiered classification of genomic tests for colorectal cancer

Aspirin: Genetics and Colorectal Cancer Risk - March 24, 2015

Precision medicine: Who benefits from Aspirin to prevent colorectal cancer? Francis Collins, NIH Director, Mar 24

Association of Aspirin and NSAID use with risk of colorectal cancer according to genetic variants.
Nan H et al. JAMA 2015 Mar 17. (11) 1133-42

Aspirin and NSAID chemoprevention, gene-environment interactions, and risk of colorectal cancer.
Wender RC et al. JAMA 2015 Mar 17. (11) 1111-2

Can Aspirin and cancer prevention be ageless companions?
Farag M et al. J Clin Diagn Res 2015 Jan (1) XE01-XE03

P342. Meta-analysis: Does aspirin or non-aspirin non-steroidal anti-inflammatory drug use reduce colorectal cancer risk in patients with inflammatory bowel disease?
J Crohns Colitis 2015 Feb S250

Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation.
Kothari N et al. Acta Oncol 2015 Apr (4) 487-92

Chemoprevention of colorectal cancer.
Lang M et al. Dig Dis 2015 (1) 58-67

Molecular pathways: Aspirin and Wnt signaling-A molecularly targeted approach to cancer prevention and treatment.
Gala MK et al. Clin. Cancer Res. 2014 Dec 11.

Gene-environment interaction involving recently identified colorectal cancer susceptibility Loci.
Kantor D et al. Cancer Epidemiol. Biomarkers Prev. 2014 Sep (9) 1824-33

Modulation of age- and cancer-associated DNA methylation change in the healthy colon by aspirin and lifestyle.
Noreen F et al. J. Natl. Cancer Inst. 2014 Jul (7)

Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD).
Fink SP et al. Sci Transl Med 2014 Apr 23. (233) 233re2

Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer.
Reimers MS et al. JAMA Intern Med 2014 May (5) 732-9

Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: colon cancer family registry.
Scherer D et al. Genes Chromosomes Cancer 2014 Jul (7) 568-78

March is Colorectal Cancer Awareness Month - March 5, 2015

CDC information: Genetic testing for hereditary colorectal cancer

CDC information: Colorectal Cancer Awareness

Screen for Life: National Colorectal Cancer Action Campaign

CDC genomics and health information: Colorectal Cancer Awareness

Listen to a CDC podcast about genetic testing for Lynch syndrome

Colorectal Cancer Screening & Prediction: Recent Genomic Insights - February 20, 2015

Role of tumour molecular and pathology features to estimate colorectal cancer risk for first-degree relatives.
Win Aung Ko et al. Gut 2015 Jan (1) 101-10

Awareness and uptake of family screening in patients diagnosed with colorectal cancer at a young age.
Hogan Niamh M et al. Gastroenterol Res Pract 2015 194931

A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS.
Rosmarin Dan et al. Gut 2015 Jan (1) 111-20

Applicability of next generation sequencing technology in microsatellite instability testing.
Gan Chun et al. Genes (Basel) 2015 (1) 46-59

A model to determine colorectal cancer risk using common genetic susceptibility loci.
Hsu Li et al. Gastroenterology 2015 Feb 12.

The impact of stratifying by family history in colorectal cancer screening programs.
Goede S Lucas et al. Int. J. Cancer 2015 Feb 6.

A stool DNA test (Cologuard) for colorectal cancer screening.
JAMA. 2014;312(23):2566.

Preliminary validation of a consumer-oriented colorectal cancer risk assessment tool compatible with the US Surgeon General's My Family Health Portrait.
Feero WG, et al. Genet Med. 2014 Dec 18

Potential of fecal microbiota for early‐stage detection of colorectal cancer.
Georg Zeller, et al. Molecular Systems Biology(2014)10:766

Valuations of genetic test information for treatable conditions: the case of colorectal cancer screening
Kilambi V, et al. Value Health 2014 Dec;17(8):838-45

Clinical potential role of circulating microRNAs in early diagnosis of colorectal cancer patients.
Du M, et al. Carcinogenesis. 2014 Dec;35(12):2723-30.

Colorectal Cancer Screening: Stool DNA Screening Test - August 21, 2014

FDA approves first non-invasive DNA screening test for colorectal cancer 

CDC information: Colorectal cancer screening tests

Multitarget stool DNA testing for colorectal-cancer screening
Imperiale T, et al. New England Journal of Medicine Mar 2014

Public stated preferences and predicted uptake for genome-based colorectal cancer screening
Groothuis-Oudshoorn CG, et al. BMC Med Inform Decis Mak 2014 Mar;14(1):18

Stool DNA and colorectal-cancer screening editorial
Robertson D, et al. New England Journal of Medicine Mar 19

Colorectal cancer screening: will non-invasive procedures triumph?
Timothy Church. Genome Medicine, June 2014