Alzheimer's Disease
Alzheimer's Disease: Genomic Insights - May 1, 2015
National plan to address Alzheimer's disease: 2014 update
Additional mechanisms conferring genetic susceptibility to Alzheimer's disease.
Calero M et al. Front Cell Neurosci 2015 138
Calero M et al. Front Cell Neurosci 2015 138
Predicting Alzheimer's disease using combined imaging-whole genome SNP data.
Kong D et al. J. Alzheimers Dis. 2015 Apr 13.
Kong D et al. J. Alzheimers Dis. 2015 Apr 13.
Polygenic overlap between C-reactive protein, plasma lipids and Alzheimer's disease.
Desikan RS et al. Circulation 2015 Apr 10.
Desikan RS et al. Circulation 2015 Apr 10.
PLD3 gene variants and Alzheimer's disease.
Hooli BV et al. Nature 2015 Apr 2. (7545) E7-8
Hooli BV et al. Nature 2015 Apr 2. (7545) E7-8
PLD3 in non-familial Alzheimer's disease.
Heilmann S et al. Nature 2015 Apr 2. (7545) E3-5
Heilmann S et al. Nature 2015 Apr 2. (7545) E3-5
PLD3 variants in population studies.
van der Lee SJ et al. Nature 2015 Apr 2. (7545) E2-3
van der Lee SJ et al. Nature 2015 Apr 2. (7545) E2-3
Genetic variability in SQSTM1 and risk of early-onset Alzheimer dementia: a European early-onset dementia consortium study.
Cuyvers E et al. Neurobiol. Aging 2015 May (5) 2005.e15-22
Cuyvers E et al. Neurobiol. Aging 2015 May (5) 2005.e15-22
A novel Alzheimer disease locus located near the gene encoding tau protein.
Jun G et al. Mol. Psychiatry 2015 Mar 17.
Jun G et al. Mol. Psychiatry 2015 Mar 17.
The biomarker and therapeutic potential of miRNA in Alzheimer's disease.
Bekris LM et al. Neurodegener Dis Manag 2015 Feb (1) 61-74
Bekris LM et al. Neurodegener Dis Manag 2015 Feb (1) 61-74
Alzheimer's Disease: Genomic Insights - March 3, 2015
Personalized Medicine for Effective Alzheimer Disease Treatment.
Kosik Kenneth S et al. JAMA Neurol 2015 Mar 2.
Kosik Kenneth S et al. JAMA Neurol 2015 Mar 2.
Association of Alzheimer's disease GWAS loci with MRI markers of brain aging.
Chauhan Ganesh et al. Neurobiol. Aging 2015 Jan 6.
Chauhan Ganesh et al. Neurobiol. Aging 2015 Jan 6.
Examination of candidate exonic variants for association to Alzheimer disease in the Amish.
D'Aoust Laura N et al. PLoS ONE 2015 (2) e0118043
D'Aoust Laura N et al. PLoS ONE 2015 (2) e0118043
The influence of genetic variants in SORL1 gene on the manifestation of Alzheimer's disease.
Louwersheimer Eva et al. Neurobiol. Aging 2014 Dec 11.
Louwersheimer Eva et al. Neurobiol. Aging 2014 Dec 11.
Identifying genetic interactions associated with late-onset Alzheimer's disease.
Floudas Charalampos S et al. BioData Min 2014 (1) 35
Floudas Charalampos S et al. BioData Min 2014 (1) 35
Genetic determinants of survival in patients with Alzheimer's disease.
Wang Xingbin et al. J. Alzheimers Dis. 2015 Feb 3.
Wang Xingbin et al. J. Alzheimers Dis. 2015 Feb 3.
Genome-wide studies of verbal declarative memory in nondemented older people: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
Debette Stéphanie et al. Biol. Psychiatry 2014 Nov 25.
Debette Stéphanie et al. Biol. Psychiatry 2014 Nov 25.
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949).
Davies G et al. Mol. Psychiatry 2015 Feb 3.
Davies G et al. Mol. Psychiatry 2015 Feb 3.
The effects of two polymorphisms on p21cip1 function and their association with Alzheimer's disease in a population of European descent.
Yates Sharon C et al. PLoS ONE 2015 (1) e0114050
Yates Sharon C et al. PLoS ONE 2015 (1) e0114050
Evaluation of candidate genes related to neuronal apoptosis in late-onset Alzheimer's disease.
Moreno-Grau Sonia et al. J. Alzheimers Dis. 2015 Jan 22.
Moreno-Grau Sonia et al. J. Alzheimers Dis. 2015 Jan 22.
Common genetic variants influence human subcortical brain structures.
Hibar Derrek P et al. Nature 2015 Jan 21.
Hibar Derrek P et al. Nature 2015 Jan 21.
Associations between biomarkers and age in the presenilin 1 E280A autosomal dominant Alzheimer disease kindred: A cross-sectional study.
Fleisher Adam S et al. JAMA Neurol 2015 Jan 12.
Fleisher Adam S et al. JAMA Neurol 2015 Jan 12.
Convergent genetic and expression data implicate immunity in Alzheimer's disease.
International Genomics of Alzheimer's Disease Consortium (IGAP). Alzheimers Dement 2014 Dec 20.
International Genomics of Alzheimer's Disease Consortium (IGAP). Alzheimers Dement 2014 Dec 20.
Alzheimer's Disease: Recent Genomic Insights - December 4, 2014
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
Monica K Wetzel-Smith et al. Nature Medicine, November 24, 2014
Monica K Wetzel-Smith et al. Nature Medicine, November 24, 2014
Genetics of Alzheimer's disease.
Chouraki V, Seshadri S. Adv Genet. 2014;87:245-94.
Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research.
O'Bryant SE et al. Alzheimers Dement. 2014 Sep 27. pii: S1552-5260(14)02765-4.
Chouraki V, Seshadri S. Adv Genet. 2014;87:245-94.
Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research.
O'Bryant SE et al. Alzheimers Dement. 2014 Sep 27. pii: S1552-5260(14)02765-4.
Alzheimer's test detects disease decade ahead of onset, by Megan Scudellari, Bloomberg News, Nov 17
New blood-based Alzheimer's biomarker panel uses exosomal miRNA, by Madeleine Johnson, GenomeWeb, Nov 21 [by free subscription only]
Alzheimer's Disease Awareness: Genetics and Family History - September 25, 2014
CDC information: September is World Alzheimer's Month- Risk factors for Alzheimer's disease include genetics
CDC report: 2013-2018 Road Map- The Healthy Brain Initiative
Alzheimer's disease genetics fact sheet, from the National Institute on Aging
Did you know? 1621 genes have been reported in relation to risk or outcomes of Alzheimer's disease, including 155 genomewide association studies? ApoE is the most commonly reported gene. To find out more, visit the HuGE Navigator
Find out what genetic conditions and tests are associated with Alzheimer's disease, NIH Genetic Testing Registry
Is Alzheimer's disease genetic? WebMD, July 2014
Alzheimer's genes: Are you at risk? Several genes have been associated with Alzheimer's disease, but more research is needed, Mayo Clinic
Alzheimer's Disease and Genetics: Recent Insights - August 21, 2014
CDC information: Facts about Alzheimer's disease
CDC report: 2013-2018 Road Map- The Healthy Brain Initiative
Did you know? 1615 genes have beern reported in relation to risk our outcomes of Alzheimer's disease, including 149 genomewide association studies? ApoE is the most commonly reported gene. To find out more, visit the HuGE Navigator
Find out what genetic conditions and tests are associated with Alzheimer's disease, NIH Genetic Testing Registry
Recent Insights
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.
Chia-Chen Liu et al. Nature Reviews Neurology 9, 106-118 (February 2013)
Chia-Chen Liu et al. Nature Reviews Neurology 9, 106-118 (February 2013)
Is apolipoprotein E required for cognitive function in humans? Implications for Alzheimer drug development
Courtney Lane-Donovan et al. JAMA Neurology, August 11, 2014
Courtney Lane-Donovan et al. JAMA Neurology, August 11, 2014
Delete ApoE gene, set back Alzheimer's, and preserve brain health? GEN News Highlights, Aug 12
Effects of the absence of apolipoprotein E on lipoproteins, neurocognitive function, and retinal function.
Mak AC et al, JAMA Neurol. 2014 Aug 11.
Mak AC et al, JAMA Neurol. 2014 Aug 11.
Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease.
Katie Lunnon et al. Nature Neuroscience, August 18, 2014
Katie Lunnon et al. Nature Neuroscience, August 18, 2014
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.
Philip L De Jager et al. Nature Neuroscience, August 18, 2014
Philip L De Jager et al. Nature Neuroscience, August 18, 2014
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