ATSDR - Toxprofile: Toxicological Profile Information Sheet

ATSDR - Toxprofile: Toxicological Profile Information Sheet

Toxicological Profiles

Information About Contaminants Found at Hazardous Waste Sites

Substance Index for ToxProfiles

Finalized toxicological profiles by chemical with NTIS order number. Updates are in bold.
* denotes tox profiles funded by the Department of Defense.

1. A
2. B
3. C
4. D
5. E
6. F
7. G
8. H
9. I
10. J
11. L
12. M
13. N
14. O
15. P
16. R
17. S
18. T
19. U
20. V
21. W
22. X
23. Z

 

A

• Acetone (PB/95/100095/AS)


• Acrolein (Updated) (PB2008-100001)


• Acrylamide (PB2013-107047)


• Acrylonitrile (PB/91/180489/AS)


• Aldrin/Dieldrin (Updated) (PB2003-100134)


• Aluminum (Updated) (PB2009-100001)


• Americium (PB2004-104396)


• Ammonia (Updated) (PBPB2004-107331)


• Antimony (PB/93/110641/AS)


• Arsenic (Updated) (PB2008-100002)


• Asbestos (Updated) (PB/2001/109101)


• Atrazine (PB2004-100001)

 

B

• 1,3-Butadiene (Updated) (PB2013-105789)


• 2,3-Benzofuran (PB/93/110666/AS)


• 2-Butanone (PB/93/110708/AS)


• Barium (Updated) (PB2008-100003)


• Benzene (Updated) (PB2008-100004)


• Benzidine (Updated) (PB/2001/109102)


• Beryllium (Updated) (PB2003-100135)


• Bis(2-chloroethyl) Ether (PB/90/168683/AS)


• Bis(chloromethyl) Ether (PB/90/168691/AS)


• Boron (Updated) (PB2010-100001)


• Bromodichloromethane (PB/90/167461/AS)


• Bromoform & Dibromochloromethane (Updated) (PB2006-100001)


• Bromomethane (PB/93/110682/AS)


• Hydrogen Sulfide / Carbonyl Sulfide (PB/99/102527/AS)*

 

C

• Cadmium (Updated) (PB2013-105787)


• Carbon Disulfide (PB97-121073)


• Carbon Monoxide (PB2013-105795)


• Carbon Tetrachloride (Updated) (PB2006-100002)


• Cesium (PB2004-104397)


• Chlordane (Updated) (PB/95/100111/AS)


• Chlordecone (PB/95/264354)


• Chlorfenvinphos (PB/98/101116/AS)


• Chlorinated Dibenzo-p-dioxins (CDDs) (Updated) (PB/99/121998)


• Chlorine (PB2010-100002)


• Chlorine Dioxide & Chlorite (PB 2004-107332)


• Chlorobenzene (PB/91/180505/AS)


• Chlorodibenzofurans (CDFs) (PB/95/100129/AS)


• Chloroethane (Updated) (PB/99/121956)


• Chloroform (Updated) (PB/98/101140/AS)


• Chloromethane (Updated) (PB/99/121964)


• Chlorophenols (Updated) (PB/99/166639)


• Chlorpyrifos (PB/98/103088/AS)


• Chromium (PB2013-105788)


• Cobalt (Updated) (PB 2004-10733)


• Copper (Updated) (PB 2004-10733)


• Creosote (Updated) (PB2003-100136)


• Cresols (Updated) (PB2009-100002)


• Cyanide (Updated) (PB2007-100674)

 

D

• 1,1-Dichloroethane (Draft for Public Comment)


• 1,1-Dichloroethene (Updated) (PB/95/100152/AS)


• 1,2-Dibromo-3-Chloropropane (PB/93/110906/AS)


• 1,2-Dibromoethane (PB/93/110740/AS)


• 1,2-Dichloroethane (Updated) (PB/2001/109103/AS)


• 1,2-Dichloroethene (Updated) (PB/97/121081/AS)


• 1,2-Dichloropropane (PB/90/182122/AS)


• 1,2-Diphenylhydrazine (Updated) (PB/91/180356/AS)


• 1,3 Dinitrobenzene & 1,3,5 Trinitrobenzene (PB/95/264289/AS)*


• 1,4-Dioxane (PB2013-105794)


• 3,3'-Dichlorobenzidine (Updated) (PB/99/121980)


• DDT, DDE, DDD (Updated) (PB2003-100137)


• Di(2-ethylhexyl)phthalate (DEHP) (Updated) (PB2003-100138)


• Di-n-butyl Phthalate (Updated) (PB/2001/109104/AS)


• Di-n-octylphthalate (DNOP) (PB/98/101033/AS)*


• Diazinon (Updated) (PB2009-100003)


• Dichlorobenzenes (Updated) (PB2007-100672)


• Dichloropropenes (Updated) (PB2009-100004)


• Dichlorvos (PB/98/101124/AS)


• Diethyl phthalate (PB/95/264214/AS)*


• Diisopropyl Methylphosphonate (DIMP) (PB/99/102535/AS)*


• Dinitrocresols (Updated) (PB/95/264321)


• Dinitrophenols (PB/95/264339)


• Dinitrotoluenes (Updated) (Draft for Public Comment)*


• Disulfoton (PB/95/264347)

 

E

• Endosulfan (Updated) (Draft for Public Comment)


• EndrinEndrin aldehyde (Updated) (PB/97/121040/AS)


• Ethion (PB/2000/108024)


• Ethylbenzene (PB2010-100004)


• Ethylene Glycol (PB2010-100005)


• Ethylene Oxide (PB/91/180554/AS)

 

F

• Fluorides, Hydrogen Fluoride, and Fluorine (Updated) (PB2004-100002)


• Formaldehyde (PB/99/166654)


• Fuel Oils / Kerosene (PB/95/264222/AS)*

 

G

• Gasoline, Automotive (PB/95/264206/AS)*


• Guthion (PB2009-100005)

 

H

• 2-Hexanone (Updated) (PB/93/110773/AS)


• Heptachlor/Heptachlor Epoxide (Updated) (PB2008-100005)


• Hexachlorobenzene (Updated) (Draft for Public Comment)


• Hexachlorobutadiene (PB/95/100160/AS)


• Hexachlorocyclohexane (HCH) (Updated) (PB2006-100003)


• Hexachlorocyclopentadiene (HCCPD) (PB/99/166670)


• Hexachloroethane (PB/98/101041/AS)*


• Hexamethylene Diisocyanate (HDI) (PB/99/102543/AS)*


• HMX (Octogen) (PB/98/101058/AS)*


• Hydraulic Fluids (PB/98/101066/AS)*


• Hydrazines (PB/98/101025/AS)*


• Hydrogen Sulfide / Carbonyl Sulfide (Updated) (Draft for Public Comment)


• n-Hexane (PB/99/166688)

 

I

• Iodine (PB2004-104399)


• Ionizing Radiation (PB/99/163388)


• Isophorone (PB/90/180225/AS)

 

J

• Jet Fuels JP-4 and JP-7 (PB/95/264230/AS)*


• Jet Fuels JP-5 and JP-8 (PB/95/264230/AS)*

 

L

• Lead (Updated) (PB2008-100007)

 

M

• 4,4'-Methylenebis(2-Chloroaniline)(MBOCA) (PB/95/100186/AS)


• 4,4'-Methylenedianiline (PB/99/102568/AS)*


• Malathion (PB2004-100003)


• Manganese (Updated) (PB2013-105793)


• Mercury (Updated) (PB/99/142416)


• Methoxychlor (Updated) (PB2003-100140)


• Methyl Mercaptan (PB/93/110799/AS)


• Methyl Parathion (PB/2001/109105/AS)


• Methyl tert-Butyl Ether (MTBE) (PB/97/121016/AS)


• Methylene Chloride (Updated) (PB/2000/108026)


• Mirex (PB/95/264354)

 

N

• n-Nitrosodi-n-propylamine (PB/90/180258/AS)


• n-Nitrosodimethylamine (PB/90/182130/AS)


• n-Nitrosodiphenylamine (Updated) (PB/93/182509/AS)


• Naphthalene, 1-Methylnapthalene, 2-Methylnapthalene (Updated) (PB2006-100004)


• Nickel (Updated) (PB2006-100005)


• Nitrobenzene (PB/91/180398/AS)


• Nitrophenols (PB/93/110823/AS)

 

O

• Otto Fuel II and its Components (PB/95/264248/AS)*

 

P

• Parathion (Draft for Public Comment)


• Pentachlorophenol (Updated) (PB/2001/109106/AS)


• Perchlorates (Updated) (PB2009-100006)


• Perfluoroalkyls (Draft for Public Comments)


• Phenol (Updated) (PB2009-100007)


• Phosphate Ester Flame Retardants (PB2013-105796)


• Plutonium (Updated) (PB2010-100006)


• Polybrominated Biphenyls (PBBs) & Polybrominated Diphenyl Ethers (PBDEs) (Updated) (PB2004-107334)


• Polychlorinated Biphenyls (PCBs) (Updated) (PB/2000/108027)


• Polycyclic Aromatic Hydrocarbons (PAHs) (Updated) (PB/95/264370)
  Acenaphthene, Acenaphthylene, Anthracene, Benzo(a)anthracene, Benzo(a)pyrene, Benzo(b)fluoranthene, Benzo(g,h,i)perylene, Benzo(k)fluoranthene, Chrysene, Dibenzo(a,h)anthracene, Fluoranthene, Fluorene, Indeno(1,2,3-cd)pyrene, Phenanthrene, Pyrene


• Propylene Glycol (Updated) (PB2009-103929)*


• Pyrethrins and Pyrethroids (PB2004-100004)


• Pyridine (PB/93/110831/AS)

 

R

• Radium (PB/91/180414/AS)


• Radon (PB2013-104879)


• RDX (Cyclonite) (PB2012-105630)*

 

S

• Selenium (Updated) (PB2004-100005)


• Silver (PB/91/180430/AS)


• Stoddard Solvent (PB/95/264263)*


• Strontium (PB2004-104400)


• Styrene (PB2010-100007)


• Sulfur Dioxide (PB/99/122020)


• Sulfur Mustard (Updated) (PB2004-100006)


• Sulfur Trioxide & Sulfuric Acid (PB99/122038)


• Synthetic Vitreous Fibers (PB2004-107335)

 

T

• 1,1,1-Trichloroethane (Updated) (PB/95/264396)


• 1,1,2,2-Tetrachloroethane (Updated) (PB2009-100008)


• 1,1,2-Trichloroethane (PB/90/196411/AS)


• 1,2,3 Trichloropropane (PB/93/110872/AS)


• 1,3,5 Trinitrobenzene & 1,3 Dinitrobenzene (PB/95/264289/AS)*
  (See 1,3-Dinitrobenzene)


• 2,4,6-Trinitrotoluene (TNT) (PB/95/264297/AS)*


• Tetrachloroethylene (PERC) (Updated) (Draft for Public Comment)


• Tetryl (PB/95/264271/AS)*


• Thallium (PB/93/110856/AS)


• Thorium (PB/91/180448/AS)


• Tin and Compounds (Updated) (PB2006-100006)


• Titanium Tetrachloride (PB/98/101082/AS)*


• Toluene (Updated) (PB/2000/108028)


• Total Petroleum Hydrocarbons (TPH) (PB/99/163370)


• Toxaphene (Updated) (Draft for Public Comments)


• Trichlorobenzenes (Draft for Public Comments)


• Trichloroethylene (TCE) (Updated) (Draft for Public Comment)


• Tungsten (PB2006-100007)

 

U

• Uranium (Updated) (PB2013-105792)


• Used Mineral-based Crankcase Oil (PB/98/101074/AS)*

 

V

• Vanadium (PB2013-105790)


• Vinyl Acetate (PB/93/110898/AS)


• Vinyl Chloride (Updated) (PB2007-100671)

 

W

• White Phosphorus (PB/98/101090/AS)*

 

X

• Xylenes (Updated) (PB2008-100008)

 

Z

• Zinc (Updated) (PB2006-100008)

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Background

By Congressional mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) produces "toxicological profiles" for hazardous substances found at National Priorities List (NPL) sites. These hazardous substances are ranked based on frequency of occurrence at NPL sites, toxicity, and potential for human exposure. Toxicological profiles are developed from a priority list of 275 substances. ATSDR also prepares toxicological profiles for the Department of Defense (DOD) and the Department of Energy (DOE) on substances related to federal sites.

Toxicological profiles are developed in two stages:

(1) DRAFTS: The toxicological profiles are first produced as drafts. ATSDR announces in the Federal Register the release of these draft profiles for a 90 day public comment period. Request draft toxicological profiles from ATSDR's Division of Toxicology and Human Health Sciences.

(2) FINALS: After the 90 day comment period, ATSDR considers incorporating all comments into the documents. ATSDR finalizes the profiles.

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NTIS address

NTIS distributes finalized toxicological profiles for a fee. For more information, contact 

National Technical Information Service 
5285 Port Royal Road
Springfield, Virginia 22161
1-800-553 6847 or 703-605-6000
Web site: http://www.ntis.gov

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Toxicological profiles "Draft for Public Comment" - CERCLA Set 24

• Trichlorobenzenes
• Toxaphene (Update)
• Perfluoroalkyls

The public comment period has ended and the profiles will be revised based on relevant public comments.

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Toxicological profiles (under development) – CERCLA Set 25

• 1,1-Dichloroethane
• Dinitrotoluenes
• Endosulfan
• Hexachlorobenzene

The public comment period has ended and the profiles will be revised based on relevant public comments.

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Toxicological profiles (under development) – CERCLA Set 26

• Glutaraldehyde*
• Hydrogen Sulfide/Carbonyl Sulfide (Update)
• Parathion
• Tetrachloroethylene (Update)
• Trichloroethylene (Update)

The public comment period ends on March 15, 2015.

*Glutaraldehyde is on a modified schedule and still under development.

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Toxicological profiles (under development) – CERCLA Set 27

• DEET
• Toluene Diisocyanate
• Nitrates/Nitrites
• Toluene (Update)
• Polybrominated Diphenyl Ethers (Update)
• Molybdenum

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Toxicological profiles (under development) – CERCLA Set 28

• Antimony (Update)
• 2,4-D
• Glyphosate
• Silica

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Department of Defense (under development) – DoD5

• Jet Fuels (JP5/8) (Update)

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Department of Defense (under development) – DoD6

• 1-Bromopropane

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List updated on December 12, 2014

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Federal Register Notices:

• FRN RDX  [PDF, 51 KB]
• FRN Uranium  [PDF, 52 KB]
• FRN Set 24 Drafts for Public Comment  [PDF, 46 KB]
• FRN Set 21 Final Profiles  [PDF, 42 KB]

Profile Development:

• Profile Development Guidance  [PDF, 2 MB]
• Profile Development Guidance Exhibits  [PDF, 1 MB]
• Profile Selection Criteria
• Federal Register Notice [PDF, 964 KB]
• Support Document  [PDF, 2.6 MB]

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Additional Resources:

• Public Health Statements (PHS) - The PHS are a series of summaries about hazardous substances taken from Chapter One of their respective ATSDR Toxicological Profiles.
• ATSDR ToxFAQsTM - The ToxFAQsTM are a series of 2-page fact sheets about hazardous substances
• ATSDR ToxGuidesTM - The ATSDR ToxGuidesTM are quick reference guides providing information such as chemical and physical properties, sources of exposure, routes of exposure, minimal risk levels, children's health, and health effects.