F10

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What is the official name of the F10 gene?

The official name of this gene is “coagulation factor X.”

F10 is the gene's official symbol. The F10 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the F10 gene?

The F10 gene provides instructions for making a protein called coagulation factor X. Coagulation factors are a group of related proteins that are involved in the coagulation system, which is a series of chemical reactions that form blood clots. After an injury, clots seal off blood vessels to stop bleeding and trigger blood vessel repair.

Coagulation factor X is made primarily by cells in the liver. The protein circulates in the bloodstream in an inactive form until the coagulation system is turned on (activated) by an injury that damages blood vessels. When coagulation factor X is activated, it interacts with other coagulation factors to convert an important coagulation protein called prothrombin to its active form, thrombin. Thrombin then converts a protein called fibrinogen into fibrin, which is the material that forms blood clots.

How are changes in the F10 gene related to health conditions?

factor X deficiency - caused by mutations in the F10 gene: At least 130 mutations in the F10 gene have been found to cause a rare bleeding disorder called factor X deficiency. This disorder commonly causes nosebleeds, easy bruising, bleeding under the skin, bleeding of the gums, blood in the urine (hematuria), and prolonged or excessive bleeding following surgery or trauma. Some F10 gene mutations that cause factor X deficiency reduce the amount of coagulation factor X in the bloodstream, resulting in a form of the disorder called type I. Other F10 gene mutations result in the production of a coagulation factor X protein with impaired function, leading to type II factor X deficiency. Reduced quantity or function of coagulation factor X prevents blood from clotting normally, causing episodes of abnormal bleeding that can be severe.

Where is the F10 gene located?

Cytogenetic Location: 13q34

Molecular Location on chromosome 13: base pairs 113,122,798 to 113,149,528

The F10 gene is located on the long (q) arm of chromosome 13 at position 34.

More precisely, the F10 gene is located from base pair 113,122,798 to base pair 113,149,528 on chromosome 13.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about F10?

You and your healthcare professional may find the following resources about F10 helpful.

Educational resources - Information pages
Biochemistry (fifth edition, 2002): Blood-Clotting Cascade (image)
Genetic Testing Registry - Repository of genetic test information (1 link)

You may also be interested in these resources, which are designed for genetics professionals and researchers.

PubMed - Recent literature
OMIM - Genetic disorder catalog
Research Resources - Tools for researchers (4 links)

What other names do people use for the F10 gene or gene products?

autoprothrombin III
prothrombinase
Prower factor
Stuart factor
Stuart-Prower factor

See How are genetic conditions and genes named? in the Handbook.

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding F10?

clotting ; coagulation ; coagulation factors ; deficiency ; fibrin ; fibrinogen ; gene ; gums ; hematuria ;injury ; protein ; surgery ; thrombin ; trauma

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

References (9 links)

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook