Avian Influenza (H7N9) Virus Infection in Chinese Tourist in Malaysia, 2014 - Volume 21, Number 1—January 2015 - Emerging Infectious Disease journal - CDC
Volume 21, Number 1—January 2015
Avian Influenza (H7N9) Virus Infection in Chinese Tourist in Malaysia, 2014
Human infection with avian influenza (H7N9) virus was first reported from China in 2013 (1). Since then, ≈400 cases have been diagnosed in China and some in Hong Kong and Taiwan. Most patients were older adults with severe community-acquired pneumonia; risk for admission to an intensive care unit is 83%, and risk for death is 27%–36% (2,3). We report avian influenza (H7N9) virus infection outside greater China, in a Chinese tourist visiting Sabah, Malaysia.
Dr. William is an infectious diseases physician at the Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia. His research interests are the epidemiology, clinical features, diagnosis, pathophysiology, and management of malaria caused by Plasmodium knowlesi.
We thank the Director General of Health, Malaysia, for permission to publish this report and Makmal Kesihatan Awam for providing and allowing us to publish the results of the investigation of possible contacts. We also thank Anupama Vasudevan for assistance with preparation of the figure.
- Gao R, Cao B, Hu Y, Feng Z, Wang D, Hu W, Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med. 2013;368:1888–97.
- Yu H, Cowling BJ, Feng L, Lau EH, Liao Q, Tsang TK, Human infection with avian influenza A H7N9 virus: an assessment of clinical severity. Lancet.2013;382:138–45.
- Gao HN, Lu HZ, Cao B, Du B, Shang H, Gan JH, Clinical findings in 111 cases of influenza A (H7N9) virus infection. N Engl J Med. 2013;368:2277–85.
- Jeyanthi S, Tengku Rogayah TAR, Thayan R, Az-Ulhusna A, Aruna A, Khebir BV, Molecular characterization of influenza A (H7N9) virus from the first imported H7N9 case in Malaysia. J Gen Mol Virol. 2014;6:19–27 .
- Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team; Dawood FS, Jain S, Finelli L, Shaw MW, Lindstrom S, Garten RJ, Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med. 2009;360:2605–15.
- Hu Y, Lu S, Song Z, Wang W, Hao P, Li J, Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. Lancet. 2013;381:2273–9.
- Li Q, Zhou L, Zhou M, Chen Z, Li F, Wu H, Epidemiology of human infections with avian influenza A(H7N9) virus in China. N Engl J Med.2014;370:520–32.
- Morens DM, Taubenberger JK, Fauci AS. Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J Infect Dis. 2008;198:962–70.
- Lin PH, Chao TL, Kuo SW, Wang JT, Hung CC, Lin HC, Virological, serological, and antiviral studies in an imported human case of avian influenza A(H7N9) virus in Taiwan. Clin Infect Dis. 2014;58:242–6 .
- Hien ND, Ha NH, Van NT, Ha NT, Lien TT, Thai NQ, Human infection with highly pathogenic avian influenza virus (H5N1) in northern Vietnam, 2004–2005. Emerg Infect Dis. 2009;15:19–23.
- Tran TH, Nguyen TL, Nguyen TD, Luong TS, Pham PM. Nguyen vV, et al. Avian influenza A (H5N1) in 10 patients in Vietnam. N Engl J Med.2004;350:1179–88.
- Butler D. Mapping the H7N9 avian flu outbreaks. Nature. 2013 Apr 24 [cited 2014 Sep 30]. http://www.nature.com/news/mapping-the-h7n9-avian-flu-outbreaks-1.12863
- Arit WG. China's outbound tourism growing by 18%—and no sign of slowing down. Forbes Asia. 2013 Nov 21 [cited 2014 Sep 30].http://www.forbes.com/sites/profdrwolfganggarlt/2013/11/21/chinas-outbound-tourism-growing-by-18-and-no-sign-of-slowing-down/
- Morens DM, Taubenberger JK, Fauci AS. H7N9 avian influenza A virus and the perpetual challenge of potential human pandemicity. mBio.2013;4:e00445–13 9
- Morens DM, Taubenberger JK, Fauci AS. Pandemic influenza viruses—hoping for the road not taken. N Engl J Med. 2013;368:2345–8.
Suggested citation for this article: William T, Thevarajah B, Lee SF, Suleiman M, Jeffree MS, Menon J, et al. Avian influenza (H7N9) virus infection in Chinese tourist in Malaysia, 2014. Emerg Infect Dis [Internet]. 2015 Jan [date cited]. http://dx.doi.org/10.3201/eid2101.141092