Cisplatin-tethered gold nanospheres for multimodal chemo-radiotherapy of glioblastoma - Nanoscale (RSC Publishing)

Cisplatin-tethered gold nanospheres for multimodal chemo-radiotherapy of glioblastoma - Nanoscale (RSC Publishing)

Cisplatin-tethered gold nanospheres for multimodal chemo-radiotherapy of glioblastoma

Sonali Setua,^ab   Myriam Ouberai,^a   Sara G. Piccirillo,^b  Colin Watts^b and   Mark Welland*^a  

Show Affiliations

Nanoscale, 2014, Advance Article

DOI: 10.1039/C4NR03693J
Received 02 Jul 2014, Accepted 21 Jul 2014
First published online 25 Jul 2014

||Share on citeulike|Share on facebook|Share on twitter|

|More

• PDF
• Rich HTML
• Add PDF to Basket (£36*)
• *Exclusive of taxes 

Download Citation

BibTex EndNote MEDLINE ProCite ReferenceManager RefWorks RIS 

Request Permissions

Please choose one of the options provided in the log in section to gain access to this content:

• Abstract
• Cited by
• Related Content

 

Glioblastoma multiforme (GBM) remains the most aggressive and challenging brain tumour to treat. We report the first successful chemo-radiotherapy on patient derived treatment resistant GBM cells using a cisplatin-tethered gold nanosphere. After intracellular uptake, the nanosphere effects DNA damage which initiates caspase-mediated apoptosis in those cells. In the presence of radiation, both gold and platinum of cisplatin, serve as high atomic number radiosensitizers leading to the emission of ionizing photoelectrons and Auger electrons. This resulted in enhanced synergy between cisplatin and radiotherapy mediated cytotoxicity, and photo/Auger electron mediated radiosensitisation leading to complete ablation of the tumour cells in an in vitro model system. This study demonstrates the potential of designed nanoparticles to target aggressive cancers in the patient derived cell lines providing a platform to move towards treatment strategies.