Opioid Painkiller Prescribing | Vital Signs

Opioid Painkiller Prescribing | Vital Signs

Painkiller Overdose: Genetic Differences in Drug Metabolism

Opioid painkiller prescribing. Where you live makes a difference, CDC Vital Signs, July 2014

CDC Vital Signs: Prescription painkiller overdoses: A growing epidemic, especially among women

CDC Vital Signs: Prescription painkiller overdoses: Use and abuse of methadone as a painkiller

Find out how opioid prescription drugs are affected by genetic differences in metabolism and which drugs have labels or dosing guidelines PharmGKB: A comprehensive resource that curates knowledge about the impact of genetic variation on drug response for clinicians and researchers

Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for cytochrome P450 2D6 (CYP2D6) genotype and codeine therapy: 2014 Update- 2014 supplement  [PDF 293.44 KB]

Podcast: New Codeine guideline and more help with pharmacogenomics

Impact of ABCB1 and CYP2B6 genetic polymorphisms on methadone metabolism, dose and treatment response in patients with opioid addiction: A systematic review and meta-analysis.
Dennis BB, et al.  PLoS One 2014 9 (1): 1. 

Genome-wide association study of opioid dependence: Multiple associations mapped to calcium and potassium pathways.  
Gelernter J, et al. Biol Psychiatry. 2014 Jul 1;76(1):66-74.

Find out genetic conditions and tests associated with opioid use and dependence, from the NIH Genetic Testing Registry