Inflammatory Bowel Disease: Genomics & Public Health

Genomics|Update|Current

Inflammatory Bowel Disease: Genomics & Public Health

CDC information: What is Inflammatory Bowel Disease (IBD)?  The greatest relative risk of IBD disease is found among first-degree relatives, suggesting a strong genetic component.

Patient page: Inflammatory bowel disease- Crohn disease and ulcerative colitis are the 2 major types of IBD
Jill Jin JAMA May 21, 2014 

The microbiome in inflammatory bowel disease: Current status and the future ahead. 
AD Kostic, et al. Gastroenterology, May 2014

Crohn disease: 82 genomewide association studies have reported on genetic factors in Crohn disease, check out the HuGE Navigator 

Ulcerative colitis: 28 genomewide association studies have reported on genetic factors, check out the HuGE Navigator
The most commonly reported genes are NOD2/CARD15 and IL23R

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease. 
Luke Jostins et al. Nature (2012)