Segmental chromosomal alterations have prognostic impact in neuroblastoma: a report from the INRG project.

Schleiermacher G, Mosseri V, London WB, Maris JM, Brodeur GM, Attiyeh E, Haber M, Khan J, Nakagawara A, Speleman F, Noguera R, Tonini GP, Fischer M, Ambros I, Monclair T, Matthay KK, Ambros P, Cohn SL, Pearson AD.

Source

1] INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France [2] Département d'Oncologie Pédiatrique, Institut Curie, 26 rue d'Ulm, Cedex 05, Paris 75248, France.

Abstract

Background:In the INRG dataset, the hypothesis that any segmental chromosomal alteration might be of prognostic impact in neuroblastoma without MYCN amplification (MNA) was tested.Methods:The presence of any segmental chromosomal alteration (chromosome 1p deletion, 11q deletion and/or chromosome 17q gain) defined a segmental genomic profile. Only tumours with a confirmed unaltered status for all three chromosome arms were considered as having no segmental chromosomal alterations.Results:Among the 8800 patients in the INRG database, a genomic type could be attributed for 505 patients without MNA: 397 cases had a segmental genomic type, whereas 108 cases had an absence of any segmental alteration. A segmental genomic type was more frequent in patients >18 months and in stage 4 disease (P<0 .0001=".0001" 11q="11q" 13="13" 17q="17q" 2012="2012" a="a" adds="adds" advance="advance" age="age" analysis="analysis" and="and" associated="associated" bjc.2012.375www.bjcancer.com.="bjc.2012.375www.bjcancer.com." cancer="cancer" clinical="clinical" deletion="deletion" doi:10.1038="doi:10.1038" efs="efs" event-free="event-free" gain="gain" genetic="genetic" genomic="genomic" importance="importance" in="in" individual="individual" information="information" journal="journal" markers="markers" mna="mna" model="model" modelling="modelling" multivariate="multivariate" neuroblastoma="neuroblastoma" not="not" of="of" onclusion:a="onclusion:a" online="online" p="p" pangenomic="pangenomic" parameters="parameters" patients="patients" poorer="poorer" profile="profile" prognostic="prognostic" publication="publication" rather="rather" respectively="respectively" retained="retained" rr="1.7," segmental="segmental" september="september" single="single" stage="stage" studies.british="studies.british" survival="survival" than="than" the="the" to="to" type="type" underlining="underlining" univariate="univariate" were="were" whereas="whereas" with="with" without="without">