lunes, 24 de septiembre de 2012

Segmental chromosomal alterations have prognosti... [Br J Cancer. 2012] - PubMed - NCBI

Segmental chromosomal alterations have prognosti... [Br J Cancer. 2012] - PubMed - NCBI

Br J Cancer. 2012 Sep 13. doi: 10.1038/bjc.2012.375. [Epub ahead of print]

Segmental chromosomal alterations have prognostic impact in neuroblastoma: a report from the INRG project.


1] INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France [2] Département d'Oncologie Pédiatrique, Institut Curie, 26 rue d'Ulm, Cedex 05, Paris 75248, France.


Background:In the INRG dataset, the hypothesis that any segmental chromosomal alteration might be of prognostic impact in neuroblastoma without MYCN amplification (MNA) was tested.Methods:The presence of any segmental chromosomal alteration (chromosome 1p deletion, 11q deletion and/or chromosome 17q gain) defined a segmental genomic profile. Only tumours with a confirmed unaltered status for all three chromosome arms were considered as having no segmental chromosomal alterations.Results:Among the 8800 patients in the INRG database, a genomic type could be attributed for 505 patients without MNA: 397 cases had a segmental genomic type, whereas 108 cases had an absence of any segmental alteration. A segmental genomic type was more frequent in patients >18 months and in stage 4 disease (P<0 .0001=".0001" 11q="11q" 13="13" 17q="17q" 2012="2012" a="a" adds="adds" advance="advance" age="age" analysis="analysis" and="and" associated="associated""" cancer="cancer" clinical="clinical" deletion="deletion" doi:10.1038="doi:10.1038" efs="efs" event-free="event-free" gain="gain" genetic="genetic" genomic="genomic" importance="importance" in="in" individual="individual" information="information" journal="journal" markers="markers" mna="mna" model="model" modelling="modelling" multivariate="multivariate" neuroblastoma="neuroblastoma" not="not" of="of" onclusion:a="onclusion:a" online="online" p="p" pangenomic="pangenomic" parameters="parameters" patients="patients" poorer="poorer" profile="profile" prognostic="prognostic" publication="publication" rather="rather" respectively="respectively" retained="retained" rr="1.7," segmental="segmental" september="september" single="single" stage="stage" studies.british="studies.british" survival="survival" than="than" the="the" to="to" type="type" underlining="underlining" univariate="univariate" were="were" whereas="whereas" with="with" without="without">
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