A clinical prediction rule for fluoroquinolone resistance in healthcare-acquired gram-negative urinary tract infection.

Rattanaumpawan P, Tolomeo P, Bilker WB, Lautenbach E.

Source

Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6021, USA.

Abstract

Data from a case-control study were used to derive and internally validate a prediction rule for identifying fluoroquinolone resistance in healthcare-acquired gram-negative urinary tract infection. This prediction rule has an excellent sensitivity and specificity (C-statistic, 0.816). External validation is necessary before implementing this rule to optimize empirical antibiotic use in clinical practice.