domingo, 29 de abril de 2012

Family history of liver cancer and hepatocellular... [Hepatology. 2012] - PubMed - NCBI

Family history of liver cancer and hepatocellular... [Hepatology. 2012] - PubMed - NCBI

Hepatology. 2012 May;55(5):1416-25. doi: 10.1002/hep.24794. Epub 2012 Mar 21.

Family history of liver cancer and hepatocellular carcinoma.

Source

Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy; Dipartimento di Medicina del Lavoro, Sezione di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy.

Abstract

Familial clustering of hepatocellular carcinoma (HCC) has been frequently reported in eastern Asiatic countries, where hepatitis B infection is common. Little is known about the relationship between family history of liver cancer and HCC in Western populations. We carried out a case-control study in Italy, involving 229 HCC cases and 431 hospital controls. Data on family history were summarized through a binary indicator (yes/no) and a family history score (FHscore), considering selected family characteristics. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were obtained from unconditional multiple logistic regression models, including terms for age, sex, study center, education, tobacco smoking, alcohol drinking, hepatitis B surface antigen, and/or anti-hepatitis C virus positivity. We also performed a meta-analysis on family history of liver cancer and liver cancer updated to April 2011 using random-effects models. After adjustment for chronic infection with hepatitis B/C viruses, family history of liver cancer was associated with HCC risk, when using both the binary indicator (OR, 2.38; 95% CI, 1.01-5.58) and the FHscore, with increasing ORs for successive score categories. Compared to subjects without family history and no chronic infection with hepatitis B/C viruses, the OR for those exposed to both risk factors was 72.48 (95% CI, 21.92-239.73). In the meta-analysis, based on nine case-control and four cohort studies, for a total of approximately 3,600 liver cancer cases, the pooled relative risk for family history of liver cancer was 2.50 (95% CI, 2.06-3.03). Conclusion: A family history of liver cancer increases HCC risk, independently of hepatitis. The combination of family history of liver cancer and hepatitis B/C serum markers is associated with an over 70-fold elevated HCC risk. (HEPATOLOGY 2011).
Copyright © 2011 American Association for the Study of Liver Diseases.
PMID:
22095619
[PubMed - in process]

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