Genetic counseling and testing for Alzheimer disea... [Genet Med. 2011] - PubMed result

Genet Med. 2011 May 16. [Epub ahead of print]
Genetic counseling and testing for Alzheimer disease: Joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors.
Goldman JS, Hahn SE, Catania JW, Larusse-Eckert S, Butson MB, Rumbaugh M, Strecker MN, Roberts JS, Burke W, Mayeux R, Bird T.


Source
From the 1Sergievsky Center and Taub Institute for Research on Alzheimer Disease and the Aging Brain, Columbia University, New York City, New York; 2John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida; 3Department of Bioethics, Case Western Reserve University, Cleveland, Ohio; 4Department of Neurology, University of Washington, Seattle Institute of Biomedical and Clinical Research, Seattle, Washington; 5Division of Medical Genetics, University of California, San Francisco, San Francisco, California; 6Department of Health Behavior & Health Education, University of Michigan School of Public Health, Ann Arbor, Michigan; 7Department of Bioethics and Humanities; and 8Division of Neurogenetics, University of Washington, Seattle, Washington.

Abstract
Alzheimer disease is the most common cause of dementia. It occurs worldwide and affects all ethnic groups. The incidence of Alzheimer disease is increasing due, in part, to increased life expectancy and the aging baby boomer generation. The average lifetime risk of developing Alzheimer disease is 10-12%. This risk at least doubles with the presence of a first-degree relative with the disorder. Despite its limited utility, patients express concern over their risk and, in some instances, request testing. Furthermore, research has demonstrated that testing individuals for apolipoprotein E can be valuable and safe in certain contexts. However, because of the complicated genetic nature of the disorder, few clinicians are prepared to address the genetic risks of Alzheimer disease with their patients. Given the increased awareness in family history thanks to family history campaigns, the increasing incidence of Alzheimer disease, and the availability of direct to consumer testing, patient requests for information is increasing. This practice guideline provides clinicians with a framework for assessing their patients' genetic risk for Alzheimer disease, identifying which individuals may benefit from genetic testing, and providing the key elements of genetic counseling for AD.

PMID:21577118[PubMed - as supplied by publisher]
Genetic counseling and testing for Alzheimer disea... [Genet Med. 2011] - PubMed result