The pharmacogenetics of antidepressant-induced mania: a systematic review and meta-analysis - Daray - 2010 - Bipolar Disorders - Wiley Online Library

Bipolar Disord. 2010 Nov;12(7):702-6. doi: 10.1111/j.1399-5618.2010.00864.x.
The pharmacogenetics of antidepressant-induced mania: a systematic review and meta-analysis.

Daray FM, Thommi SB, Ghaemi SN.

Hospital Neuropsiquiátrico Braulio A. Moyano, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Boston, MA, USA.

Abstract

Daray FM, Thommi SB, Ghaemi SN. The pharmacogenetics of antidepressant-induced mania: a systematic review and meta-analysis.
Bipolar Disord 2010: 12: 702-706. © 2010 The Authors.
Journal compilation © 2010 John Wiley & Sons A/S. Objective:  Antidepressant-induced mania (AIM) has been associated with the serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism in some studies but not in others. We conducted a meta-analysis of those studies and other studies of genetic predictors of AIM. Methods:  MEDLINE-based searches of genetic studies of AIM were conducted, and a meta-analysis of six studies of 5-HTTLPR was performed. Other polymorphisms were insufficiently studied to allow for meta-analysis. Results:  There was an association of the short (s) variant of 5-HTTLPR and AIM [risk ratio (RR) = 1.35, 95% confidence interval (CI): 1.04-1.76, p = 0.02]. There was a higher frequency of s carriers (sl and ss genotypes) in those who developed AIM [RR = 1.38, 95% CI: 0.98-1.93), p = 0.06]. Conclusion:  The 5-HTTLPR polymorphism appears to have a moderate effect size association with AIM in patients with bipolar disorder.
© 2010 John Wiley and Sons A/S.

PMID: 21040287 [PubMed - in process]

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The pharmacogenetics of antidepressant-induced mania: a systematic review and meta-analysis - Daray - 2010 - Bipolar Disorders - Wiley Online Library