martes, 30 de noviembre de 2010

Pandemic (H1N1) 2009 Virus and Other Respiratory Pathogens | CDC EID

EID Journal Home > Volume 16, Number 12–December 2010
Volume 16, Number 12–December 2010
Co-detection of Pandemic (H1N1) 2009 Virus and Other Respiratory Pathogens

Kassi Koon, Catherine M. Sanders, Comments to Author Jessica Green, Leslie Malone, Holly White, Delineliz Zayas, Rebecca Miller, Stanley Lu, and Jian Han
Author affiliations: HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA (K. Koon, C.M. Sanders, J. Han); and Diatherix Laboratories, Huntsville (J. Green, L. Malone, H. White, D. Zayas, R. Miller, S. Lu)

Suggested citation for this article

From May through October 2009, a total of 10,624 clinical samples from 23 US states were screened for multiple respiratory pathogen gene targets. Of 3,110 (29.3%) samples positive for pandemic (H1N1) 2009 virus, 28% contained >1 other pathogen, most commonly Staphylococcus aureus (14.7%), Streptococcus pneumoniae (10.2%), and Haemophilus influenzae (3.5%).

For previous and current influenza A pandemics, postmortem studies have established a strong link between secondary bacterial infections and increased deaths (1,2). Numerous respiratory pathogens can be detected from a single sample by using a multiplex molecular method called target-enriched multiplex PCR (3–6). During the 2006 influenza season, this method was used at Vancouver Children and Women's Hospital to study 1,742 patients with acute respiratory infections; >2 pathogens were detected for ≈27% of patients studied (7). We used this method to learn more about infections occurring concurrently with pandemic (H1N1) 2009.

Pandemic (H1N1) 2009 Virus and Other Respiratory Pathogens | CDC EID

Suggested Citation for this Article

Koon K, Sanders CM, Green J, Malone L, White H, Zayas D, et al. Co-detection of pandemic (H1N1) 2009 virus and other respiratory pathogens. Emerg Infect Dis [serial on the Internet]. 2010 Dec [date cited].

DOI: 10.3201/eid1612.091697

Comments to the Authors

Please use the form below to submit correspondence to the authors or contact them at the following address:

Catherine M. Sanders, HudsonAlpha Institute of Biotechnology–Han Lab, 601 Genome Way, Huntsville, AL 35806, USA;

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