Timing is critical: Gene, environment and timing i... [Eur Psychiatry. 2010] - PubMed result

Eur Psychiatry. 2010 May 3. [Epub ahead of print]

Timing is critical: Gene, environment and timing interactions in genetics of suicide in children and adolescents.
Zalsman G.

Child and Adolescent Psychiatry Division, Geha Mental Health Center, PO Box 102, 49100 Petach Tiqwa, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Molecular Imaging and Neuropathology Devision, Psychitry Department, Columbia University, New York, USA.

Abstract
Suicidal behavior runs in families and is prevalent in adolescence. Case-control and family-based studies in this age group failed to find a genetic association that survived replications. Gene environment approach gave new hope for possible associations especially with the short allele of the serotonin transporter promoter polymorphism (5-HTTLPR). However, a recent meta-analysis raised doubts about the consistency of these findings. Some new structural and functional imaging data may shade light on the age-related and gender-related development of the brain. This review suggests a new approach to gene by environment and timing interaction to understand the interplay that leads to suicidality in adolescents and young adults. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

PMID: 20444577 [PubMed - as supplied by publisher]

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Timing is critical: Gene, environment and timing i... [Eur Psychiatry. 2010] - PubMed result