Family history of cancer and renal cell cancer ris... [Br J Cancer. 2010] - PubMed result

Br J Cancer. 2010 May 4. [Epub ahead of print]

Family history of cancer and renal cell cancer risk in Caucasians and African Americans.
Karami S, Schwartz K, Purdue MP, Davis FG, Ruterbusch JJ, Munuo SS, Wacholder S, Graubard BI, Colt JS, Chow WH.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7242, Bethesda, MD 20892-7242, USA.

Abstract
Background:The association between renal cell carcinoma (RCC) risk and family history of cancer has not been examined with an adequate number of African Americans (AAs).Methods:In a population-based case-control study, unconditional logistic regression was used to calculate the association between RCC risk and a family history of cancer among 1217 RCC cases and 1235 controls.Results:Increased RCC risk was shown for subjects with at least one first-degree relative with kidney cancer (odds ratio=2.29; 95% confidence interval=1.31-4.00). No differences in risk were observed when analyses were stratified by race. For Caucasians, excess risk was observed among those reporting a sibling with kidney cancer, whereas for AAs, increased risk occurred among subjects reporting either a sibling or parent affected with the disease. A family history of non-renal cancers, and those related to smoking or to the von Hippel-Lindau syndrome, revealed no association with RCC risk.Conclusion:The RCC risk associated with a family history of kidney cancer is similar among Caucasians and AAs.British Journal of Cancer advance online publication, 4 May 2010; doi doi:10.1038/sj.bjc.6605680 www.bjcancer.com.

PMID: 20442711 [PubMed - as supplied by publisher]

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Family history of cancer and renal cell cancer ris... [Br J Cancer. 2010] - PubMed result