Vascular tone and the genomics of hypertension. [Heart Fail Clin. 2010] - PubMed result

Heart Fail Clin. 2010 Jan;6(1):45-53.

Vascular tone and the genomics of hypertension.
Sheppard R.

Heart Function Clinic, Jewish General Hospital, McGill University, 377 Cote St Catherine Road, Montreal, Quebec H3T 1E2, Canada. richard.sheppard@mcgill.ca

Hypertension is a common condition that is a well-described risk factor for the development of cerebrovascular disease, myocardial infarction and heart failure. Medical therapy for hypertension may not only prevent development of these potentially devastating illnesses but may be used to treat high blood pressure, which coexists with these conditions. Therapeutic response to medical therapy for hypertension is variable and may be related to the individual genetic profile of patients. We have described here only several of the HTN-related polymorphisms that may impact clinical response in patients who have high blood pressure and coexisting conditions. Future studies are needed to identify other potential genotypes that may influence therapeutic response in addition to clinical trials of specific medical therapy in individual patients based on specific genotypes.

PMID: 19945060 [PubMed - in process]

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Vascular tone and the genomics of hypertension. [Heart Fail Clin. 2010] - PubMed result