Advances in X chromosome inactivation open therapeutic opportunities for X-linked genetic disorders

https://www.news-medical.net/news/20260803/Advances-in-X-chromosome-inactivation-open-therapeutic-opportunities-for-X-linked-genetic-disorders.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=rare_diseases_newsletter_10_august_2026 A new review explores how advances in understanding X chromosome inactivation (XCI) are creating potential therapeutic opportunities for a range of X-linked genetic disorders, including Rett syndrome, Fabry disease, Duchenne muscular dystrophy, hemophilia, and others. The article examines the molecular mechanisms that control X chromosome silencing, the impact of skewed XCI on disease severity, emerging methods to measure XCI patterns, and experimental approaches aimed at reactivating beneficial genes on the inactive X chromosome.