A microglial transition could mean the difference between a healthy brain and Alzheimer’s disease Some people with amyloid plaques and tau tangles in their brain never develop Alzheimer’s disease. New research suggests it comes down to microglial activity. Written byAllison Whitten, PhD

https://www.drugdiscoverynews.com/a-microglial-transition-could-mean-the-difference-between-a-healthy-brain-and-alzheimer-s-disease-17273 Whether or not someone develops Alzheimer’s disease could be the result of a key transition in microglial activity, according to new research published recently in Nature Medicine. Researchers led by Mark Fiers at KU Leuven and Bart De Strooper at the University College London, in collaboration with Muna Therapeutics, found that microglia switch from an early inflammatory response in the presence of amyloid plaques to an antigen-presenting state that coincides with the development of tau tangles.