HSPA5 is an essential host factor for Ebola vi... [Antiviral Res. 2014] - PubMed - NCBI

HSPA5 is an essential host factor for Ebola vi... [Antiviral Res. 2014] - PubMed - NCBI

Antiviral Res. 2014 Jul 11;109C:171-174. doi: 10.1016/j.antiviral.2014.07.004. [Epub ahead of print]

HSPA5 is an essential host factor for Ebola virus infection.

Patrick Reid S1, Shurtleff AC1, Costantino JA1, Tritsch SR1, Retterer C1, Spurgers KB1, Bavari S2.

Author information

Abstract

Development of novel strategies targeting the highly virulent ebolaviruses is urgently required. A proteomic study identified the ER chaperone HSPA5 as an ebolavirus-associated host protein. Here, we show using the HSPA5 inhibitor (-)- epigallocatechin gallate (EGCG) that the chaperone is essential for virus infection, thereby demonstrating a functional significance for the association. Furthermore, in vitro and in vivo gene targeting impaired viral replication and protected animals in a lethal infection model. These findings demonstrate that HSPA5 is vital for replication and can serve as a viable target for the design of host-based countermeasures.

Published by Elsevier B.V.

KEYWORDS:

Antiviral; Ebolavirus; HSPA5

PMID:

 

25017472

 

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