Antiviral Res. 2014 Jul 11;109C:171-174. doi: 10.1016/j.antiviral.2014.07.004. [Epub ahead of print]
HSPA5 is an essential host factor for Ebola virus infection.
Development of novel strategies targeting the highly virulent ebolaviruses is urgently required. A proteomic study identified the ER chaperone HSPA5 as an ebolavirus-associated host protein. Here, we show using the HSPA5 inhibitor (-)- epigallocatechin gallate (EGCG) that the chaperone is essential for virus infection, thereby demonstrating a functional significance for the association. Furthermore, in vitro and in vivo gene targeting impaired viral replication and protected animals in a lethal infection model. These findings demonstrate that HSPA5 is vital for replication and can serve as a viable target for the design of host-based countermeasures.
Published by Elsevier B.V.
Antiviral; Ebolavirus; HSPA5
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