lunes, 21 de julio de 2014

Association between alcohol and cardiovascular disease: ... [BMJ. 2014] - PubMed - NCBI

Association between alcohol and cardiovascular disease: ... [BMJ. 2014] - PubMed - NCBI



 2014 Jul 10;349:g4164. doi: 10.1136/bmj.g4164.

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.

Holmes MV1Dale CE2Zuccolo L3Silverwood RJ4Guo Y5Ye Z6Prieto-Merino D2Dehghan A7Trompet S8Wong A9Cavadino A10Drogan D11,Padmanabhan S12Li S13Yesupriya A14Leusink M15Sundstrom J16Hubacek JA17Pikhart H18Swerdlow DI19Panayiotou AG20Borinskaya SA21Finan C19Shah S22Kuchenbaecker KB23Shah T19Engmann J19Folkersen L24Eriksson P24Ricceri F25Melander O26Sacerdote C25Gamble DM27,Rayaprolu S28Ross OA28McLachlan S29Vikhireva O18Sluijs I30Scott RA6Adamkova V31Flicker L32Bockxmeer FM33Power C10Marques-Vidal P34,Meade T2Marmot MG35Ferro JM36Paulos-Pinheiro S37Humphries SE38Talmud PJ38Mateo Leach I39Verweij N39Linneberg A40Skaaby T40,Doevendans PA41Cramer MJ41Harst Pv42Klungel OH15Dowling NF14Dominiczak AF12Kumari M19Nicolaides AN43Weikert C11Boeing H11Ebrahim S2Gaunt TR3Price JF29Lannfelt L44Peasey A18Kubinova R45Pajak A46Malyutina S47Voevoda MI48Tamosiunas A49Maitland-van der Zee AH15,Norman PE50Hankey GJ51Bergmann MM11Hofman A7Franco OH7Cooper J52Palmen J38Spiering W53Jong PA54Kuh D9Hardy R9Uitterlinden AG7Ikram MA7Ford I55Hyppönen E56Almeida OP57Wareham NJ6Khaw KT58Hamsten A59Husemoen LL40Tjønneland A60Tolstrup JS61Rimm E62Beulens JW30Verschuren WM63Onland-Moret NC30Hofker MH64Wannamethee SG65Whincup PH66Morris R65Vicente AM67Watkins H68Farrall M68Jukema JW8Meschia J27Cupples LA69Sharp SJ6Fornage M70Kooperberg C71LaCroix AZ71Dai JY71Lanktree MB72Siscovick DS73Jorgenson E74Spring B75Coresh J76Li YR77Buxbaum SG78Schreiner PJ79Ellison RC80Tsai MY81Patel SR82Redline S83Johnson AD84Hoogeveen RC85,Hakonarson H86Rotter JI87Boerwinkle E88Bakker PI89Kivimaki M18Asselbergs FW90Sattar N91Lawlor DA3Whittaker J92Davey Smith G3Mukamal K93Psaty BM94Wilson JG95Lange LA96Hamidovic A97Hingorani AD19Nordestgaard BG98Bobak M18Leon DA2Langenberg C6Palmer TM99Reiner AP71Keating BJ100Dudbridge F2Casas JP101InterAct Consortium.

Abstract

OBJECTIVE:

To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease.

DESIGN:

Mendelian randomisation meta-analysis of 56 epidemiological studies.

PARTICIPANTS:

261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers.

MAIN OUTCOME MEASURES:

Odds ratio for coronary heart disease and stroke associated with the ADH1B variant in all individuals and by categories of alcohol consumption.

RESULTS:

Carriers of the A-allele of ADH1B rs1229984 consumed 17.2% fewer units of alcohol per week (95% confidence interval 15.6% to 18.9%), had a lower prevalence of binge drinking (odds ratio 0.78 (95% CI 0.73 to 0.84)), and had higher abstention (odds ratio 1.27 (1.21 to 1.34)) than non-carriers. Rs1229984 A-allele carriers had lower systolic blood pressure (-0.88 (-1.19 to -0.56) mm Hg), interleukin-6 levels (-5.2% (-7.8 to -2.4%)), waist circumference (-0.3 (-0.6 to -0.1) cm), and body mass index (-0.17 (-0.24 to -0.10) kg/m(2)). Rs1229984 A-allele carriers had lower odds of coronary heart disease (odds ratio 0.90 (0.84 to 0.96)). The protective association of the ADH1B rs1229984 A-allele variant remained the same across all categories of alcohol consumption (P=0.83 for heterogeneity). Although no association of rs1229984 was identified with the combined subtypes of stroke, carriers of the A-allele had lower odds of ischaemic stroke (odds ratio 0.83 (0.72 to 0.95)).

CONCLUSIONS:

Individuals with a genetic variant associated with non-drinking and lower alcohol consumption had a more favourable cardiovascular profile and a reduced risk of coronary heart disease than those without the genetic variant. This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health.
© Holmes et al 2014.

PMID:
 
25011450
 
[PubMed - in process] 
PMCID:
 
PMC4091648
 
Free PMC Article

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