lunes, 21 de julio de 2014

Characteristics of Adults in the ... [Clin Gastroenterol Hepatol. 2014] - PubMed - NCBI

Characteristics of Adults in the ... [Clin Gastroenterol Hepatol. 2014] - PubMed - NCBI

 2014 Jul 7. pii: S1542-3565(14)00976-8. doi: 10.1016/j.cgh.2014.06.028. [Epub ahead of print]

Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and HBV Genotype.



Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the US and Canada might be disproportionately affected. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network.


The HBRN collected data on clinical characteristics of 1625 adults with chronic HBV infection who are not receiving antiviral therapy from 21 clinical centers in North America.


Half of the subjects in the HBRN are male, and the mean age is 42 years; 72% are Asian, 15% are Black, and 11% are White, with 82% born outside of North America. The most common HBV genotype was B (39%); 745 of subjects were negative for the hepatitis B e antigen. The median serum level of HBV DNA when the study began was 3.6 log10 IU/mL; 68% of male subjects and 67% of female subjects had levels of alanine aminotransferase above the normal range.


The HBRN cohort will be used to address important clinical and therapeutic questions for North Americans infected with chronic HBV and to guide health policies on HBV prevention and management in North America.
Copyright © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.


ALT; Chronic hepatitis B virus infection; HBeAg; USA

[PubMed - as supplied by publisher]

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