Study Upends Common View of Inflammatory Signal Transduction Sarah Amandolare

https://www.medscape.com/viewarticle/study-upends-common-view-inflammatory-signal-transduction-2026a10015m8?src= For decades, researchers have been trying to treat inflammation in infection, autoimmune and immune-mediated diseases, and cancer by targeting Toll-like receptors. Because these receptors turn on the pathway to increased expression of proinflammatory genes, turning them off seems like a logical approach. And yet, “there’s example after example in the literature of failures in that space,” said Jonathan C. Kagan, PhD, a professor of pediatrics at Harvard Medical School in Boston. “Why would those drugs not work?”