A new design framework for mRNA vaccines could improve efficacy and safety New findings suggest that the location of mRNA expression in the body plays a critical role in shaping T cell responses, opening the door to more precise and effective mRNA-based treatments. Written byBree Foster, PhD

A new design framework for mRNA vaccines could improve efficacy and safety New findings suggest that the location of mRNA expression in the body plays a critical role in shaping T cell responses, opening the door to more precise and effective mRNA-based treatments. Written byBree Foster, PhD https://www.drugdiscoverynews.com/a-new-design-framework-for-mrna-vaccines-could-improve-efficacy-and-safety-17156?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-8BkiQlfgKupbgtgkPrIsp4q-9MnAX2SQCInw2rIx_ZYNLoWoNASkJ_EtXseBqAy-9zexcz-OjEDUIc1telNsOwcIVzqg&_hsmi=444112830&utm_content=444112830&utm_source=hs_email A new study from the Icahn School of Medicine at Mount Sinai challenges a central assumption in mRNA vaccine biology, showing that immune cells are not the only — or even the primary — determinant of vaccine effectiveness. Instead, non-immune cells such as muscle and liver cells play a previously underappreciated role in shaping immune responses, with major implications for mRNA vaccines and therapeutics. The preclinical research, published in Nature Biotechnology, also introduces a programmable system that allows scientists to control which cell types express mRNA-encoded proteins. In mouse models, this approach significantly improved the efficacy of an mRNA cancer vaccine for lymphoma.