Tirzepatide: Modest Weight Regain, Sustained Glycemic Gains Over 3 Years September 24, 2026

https://www.medscape.com/viewarticle/tirzepatide-modest-weight-regain-sustained-glycemic-gains-2026a1000zo4?ecd=wnl_tp10_daily_260926_MSCPEDIT_etid8728689&uac=148436CN&impID=8728689 In a 3-year analysis of the SURMOUNT-1 trial, most participants with obesity or overweight and prediabetes who reached their lowest weight on tirzepatide had regained little of it by the end of the study — 70% regained less than 5% of their baseline weight. Even with some rebound, patients retained most of their metabolic gains — suggesting a small amount of regain is not necessarily a cause for concern.