BRCA Mutation Carriers Likely to Have Risk-Reducing Surgery Edited by Katie Lennon September 07, 2026

https://www.medscape.com/viewarticle/brca-mutation-carriers-likely-have-risk-reducing-surgery-2026a1000x44?src= Women with pathogenic variants (PVs) in BRCA1/2 genes were more than seven times as likely to undergo risk-reducing mastectomy (RRM) and risk-reducing salpingo-oophorectomy (RRSO) as were those carrying genetic variants for which there is “insufficient evidence” for discussion, consideration, or recommendation related to use of either procedure for such patients. Pancreatic screening via endoscopic ultrasound (EUS) or magnetic resonance cholangiopancreatography (MRCP) was used by fewer than 11% of eligible women, regardless of gene type, within 12 months after genetic testing.