Bilateral Mastectomy Rises in Young BRCA1/2 Carriers Edited by Victoria Stern September 07, 2026

https://www.medscape.com/viewarticle/bilateral-mastectomy-rises-young-brca1-2-carriers-2026a1000wsl?src= Among young women carrying germline BRCA1/2 pathogenic or likely pathogenic variants diagnosed with early-onset breast cancer, bilateral mastectomy rates increased substantially over two decades, rising from 8% in 2000 to 44.4% in 2020, a recent international study found. Women who underwent genetic testing before or at the time of diagnosis were significantly more likely to undergo bilateral mastectomy compared with those tested after diagnosis.