Medscape Now! Rising Early-Onset Uterine Cancer: Disparities and Risk Factors Authors: ​Naseem Bazargan, MPH

https://www.medscape.org/viewarticle/medscape-now-rising-early-onset-uterine-cancer-disparities-2026a1000gb5?page=1 Uterine cancer is the most common gynecological cancer in the United States,[1] and in recent years, concern has increased regarding rising uterine cancer incidence at younger ages.[2] To better characterize early-onset cancer risk (ie, cancer onset before age 50) in the United States, a recent population-level, epidemiologic study analyzed trends in cancer incidence and mortality rates across early-onset (ages 15-49) and older-onset (ages 50-79) age groups from 2010 to 2019 (incidence) and 2010 to 2022 (mortality). Researchers found that uterine cancer incidence increased across all early-onset age groups: Per year, incidence rose 2.2% (95% CI: 0.7%, 3.8%) in individuals aged 15 to 29 years; 2.6% (95% CI: 1.6%, 3.8%) in individuals aged 30 to 39 years; and 1.8% (95% CI: 0.7%, 3.0%) in individuals aged 40 to 49 years. Notably, uterine cancer was also among the 9 cancers where incidence increased in at least 1 older-onset age group, in this case 1.7% (95% CI: 1.3%, 2.2%) annually among individuals aged 70 to 79 years (Figure).