How Gut Fungi and Archaea Influence Human Health

https://www.news-medical.net/health/How-Gut-Fungi-and-Archaea-Influence-Human-Health.aspx The non-bacterial gut microbiome, particularly fungi and archaea, plays an important role in metabolism, immune regulation, and microbial ecosystem stability through complex interactions with bacteria and the host. Emerging research links fungal dysbiosis and methanogenic archaea to obesity, inflammatory disorders, gastrointestinal disease, and potential future microbiome-based therapies. The gut microbiome comprises bacteria, fungi, archaea, viruses, and other microorganisms that influence health and disease. The biological significance of intestinal bacteria is well-established; however, recent advances in sequencing technologies indicate that both the gut mycobiome and archaeome are involved in metabolism, immune regulation, and microbial balance that influence the risk of developing obesity, inflammatory disorders, and diseases of the gastrointestinal tract.1,2,3 Although fungi represent only a small fraction of total gut microbes, they can have disproportionate effects through immune signaling, microbial competition, and interactions with bacteria