Pancreatic Cancer: Difficult Diagnosis, Ominous Outlook Roman Leonid Kleynberg, MD; Gennadiy (Henry) Guralnik; Katherine Pabon; Sean Ross Lazaro | February 11, 2026 |

https://reference.medscape.com/slideshow/pancreatic-cancer-6015119?ecd=wnl_critimg_260220_mscpref_etid8117243&uac=148436CN&impID=8117243 Pancreatic cancer remains a leading cause of death, with the American Cancer Society estimating 67,440 new cases and 51,980 deaths in 2025. While the average 5-year survival rate has risen to 13.3%, outcomes stay heavily dependent on the cancer’s stage at diagnosis.