The long noncoding RNA MALAT‐1 functions as a competing endogenous RNA to regulate MSL2 expression by sponging miR‐338‐3p in myasthenia gravis - Kong - 2019 - Journal of Cellular Biochemistry - Wiley Online Library

The long noncoding RNA MALAT‐1 functions as a competing endogenous RNA to regulate MSL2 expression by sponging miR‐338‐3p in myasthenia gravis - Kong - 2019 - Journal of Cellular Biochemistry - Wiley Online Library

The long noncoding RNA MALAT‐1 functions as a competing endogenous RNA to regulate MSL2 expression by sponging miR‐338‐3p in myasthenia gravis

Xiaotong Kong 

 

Jianjian Wang 

 

Yuze Cao 

 

Huixue Zhang 

 

Xiaoyu Lu 

 

Yu Wang 

 

Chunrui Bo 

 

Tianfeng Wang 

 

Shuang Li 

 

Kuo Tian 

 

Zhaojun Liu 

 

Lihua Wang

First published: 26 October 2018

 

https://doi.org/10.1002/jcb.27838

Citations: 3

Xiaotong Kong and Jianjian Wang have contributed equally to this study.

Abstract

Myasthenia gravis (MG) is a cell‐dependent autoimmune disease commonly associated with thymic pathology. Metastasis‐associated lung adenocarcinoma transcript 1 (MALAT‐1) has been associated with gene regulation and alternative splicing. It has shown relationship with proliferation, apoptosis, migration, and invasion. In this study, we found that MALAT‐1 expression was downregulated in MG. The level of the miR‐338‐3p was increased in peripheral blood mononuclear cells from MG patients compared with those from control subjects. MALAT‐1 competed for binding to miR‐338‐3p with male‐specific lethal 2 (MSL2) in luciferase reporter assays. We confirmed the MALAT‐1‐miR‐338‐3p‐MSL2 interaction network in MG in vitro. Thus, MALAT‐1 directly induced MSL2 expression in MG by acting as a competing endogenous RNA for miR‐338‐3p, suggesting that it may serve as a therapeutic target for MG treatment.