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- Big Data and Collaboration Seek to Fight COVID-19
E Yazinski, The Scientist, July 21, 2020
Researchers try unprecedented data sharing and cooperation to understand COVID-19—and develop a model for diseases beyond the coronavirus pandemic. - Genomics and epidemiological surveillance
SW Low et al, Nat Rev Micro, July 25, 2020
The timely detection and surveillance of infectious diseases and responses to pandemics are crucial but challenging. Whole-genome sequencing (WGS) is a common tool for pathogen identification and tracking, establishing transmission routes and outbreak control. - Molecular Underpinnings of Severe Coronavirus Disease 2019
RM Plenge, JAMA, July 24, 2020 - Presence of Genetic Variants Among Young Men With Severe COVID-19
CI van der Made et al, JAMA, July 24, 2020In 4 young male patients with severe COVID-19 from 2 families, rare loss-of-function variants of the X-chromosomal TLR7 were identified, with immunological defects in type I and II interferon production. These findings provide insights into the pathogenesis of COVID-19. - Estimated County-Level Prevalence of Selected Underlying Medical Conditions Associated with Increased Risk for Severe COVID-19 Illness - United States, 2018.
Razzaghi Hilda et al. MMWR. Morbidity and mortality weekly report 2020 Jul 69(29) 945-950The median model-based estimate of the prevalence of any of five underlying medical conditions associated with increased risk for severe COVID-19–associated illness among U.S. adults was 47.2% among 3,142 U.S. counties. The estimated number of persons with these conditions followed population distributions, but prevalence was higher in more rural counties. - A country level analysis measuring the impact of government actions, country preparedness and socioeconomic factors on COVID-19 mortality and related health outcomes
R Chaudry et al, E Clinical Medicine, July 23, 2020 - Mathematical models to guide pandemic response
CJE Metcalf et al, Science, July 23, 2020Despite the devastating burden that COVID-19 has imposed so far, most of the world is still susceptible to SARS-CoV-2 infection. Models projecting into this future have evaluated policy scenarios and assessed the potential impact of seasonal variation in transmission. - The role of chest radiography in confirming covid-19 pneumonia.
Cleverley Joanne et al. BMJ (Clinical research ed.) 2020 370m2426A normal chest radiograph does not exclude covid-19 pneumonia. No single feature of covid-19 pneumonia on a chest radiograph is specific or diagnostic, but a combination of multifocal peripheral lung changes of ground glass opacity and/or consolidation, which are most commonly bilateral, may be present. - Artificial intelligence mobile health platform for early detection of COVID-19 in quarantine subjects using a wearable biosensor: protocol for a randomised controlled trial.
Wong Chun Ka, et al. BMJ open 2020 7 0. (7) e038555 - Drawing insights from COVID-19-infected patients using CT scan images and machine learning techniques: a study on 200 patients.
Sharma Sachin, et al. Environmental science and pollution research international 2020 7 0. - Digital pathology in the time of corona.
Stathonikos Nikolas, et al. Journal of clinical pathology 2020 7 0. - An analysis of the domestic resumption of social production and life under the COVID-19 epidemic.
Xu Xinliang, et al. PloS one 2020 0 0. (7) e0236387 - A real-world disproportionality analysis of FDA Adverse Event Reporting System (FAERS) events for baricitinib.
Peng Ling, et al. Expert opinion on drug safety 2020 7 0. - Artificial intelligence in ophthalmology during COVID-19 and in the post COVID-19 era.
Hallak Joelle A, et al. Current opinion in ophthalmology 2020 7 0. - COVID-19 and Cataract Surgery Backlog in Medicare Beneficiaries.
Aggarwal Shruti, et al. Journal of cataract and refractive surgery 2020 7 0. - Predicting Mechanical Ventilation Requirement and Mortality in COVID-19 using Radiomics and Deep Learning on Chest Radiographs: A Multi-Institutional Study.
Bae Joseph, et al. ArXiv 2020 7 0. - Histopathological Study of a Broad Spectrum of Skin Dermatoses in Patients Affected or Highly Suspected of Infection by COVID-19 in the Northern Part of Italy: Analysis of the Many Faces of the Viral-Induced Skin Diseases in Previous and New Reported Cases.
Gianotti Raffaele, et al. The American Journal of dermatopathology 2020 8 0. (8) 564-570 - Geographic components of SARS-CoV-2 expansion: a hypothesis.
Joyce Kelsey E, et al. Journal of applied physiology (Bethesda, Md. : 1985) 2020 7 0. - Emergence of European and North American mutant variants of SARS-CoV-2 in Southeast Asia.
Islam Ovinu Kibria, et al. Transboundary and emerging diseases 2020 7 0. - Dual inhibitors of SARS-CoV-2 proteases: pharmacophore and molecular dynamics based drug repositioning and phytochemical leads.
Mitra Kartik, et al. Journal of biomolecular structure & dynamics 2020 7 0. 1-14 - SARS-CoV-2 genomic variations associated with mortality rate of COVID-19.
Toyoshima Yujiro, et al. Journal of human genetics 2020 7 0. - Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures.
Vanderheiden Abigail, et al. Journal of virology 2020 7 0. - Virological surveillance of SARS-CoV-2 in an Italian northern area: comparison of Real Time RT PCR cycle threshold (Ct) values in three epidemic periods.
Veronesi Licia, et al. Acta bio-medica : Atenei Parmensis 2020 7 0. (9-S) 19-21 - Point-of-Use Rapid Detection of SARS-CoV-2: Nanotechnology-Enabled Solutions for the COVID-19 Pandemic.
Rabiee Navid, et al. International journal of molecular sciences 2020 7 0. (14) - Identification and Analysis of Unstructured, Linear B-Cell Epitopes in SARS-CoV-2 Virion Proteins for Vaccine Development.
Corral-Lugo Andrés, et al. Vaccines 2020 7 0. (3) - Tiotropium is Predicted to be a Promising Drug for COVID-19 Through Transcriptome-Based Comprehensive Molecular Pathway Analysis.
Kang Keunsoo, et al. Viruses 2020 7 0. (7) - Clock genes may drive seasonal variation in SARS-CoV-2 infectivity: are we due for a second wave of COVID-19 in the fall?
Goren A, et al. Journal of biological regulators and homeostatic agents 2020 7 0. (4) - Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization.
Wang Bei, et al. bioRxiv : the preprint server for biology 2020 7 0. - Endocrine disrupting chemicals and COVID-19 relationships: a computational systems biology approach.
Wu Qier, et al. medRxiv : the preprint server for health sciences 2020 7 0. - Structure of human steroid 5α-reductase 2 with anti-androgen drug finasteride.
Xiao Qingpin, et al. Research square 2020 7 0.
Disclaimer: Articles listed in the Public Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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