CIENCIASMEDICASNEWS: Quantifying AAV critical quality attributes

jueves, 26 de marzo de 2020

Quantifying AAV critical quality attributes

	Immunology
	The latest immunology news from News Medical

Aging immune cells increase risk for macular degeneration

Quantifying AAV critical quality attributes

CQAs of viral vectors for gene therapy include viral capsid titer, ratio of empty and full capsids, and percent aggregate. These are rapidly measured by SEC-MALS, combining size-exclusion chromatography with multi-angle light scattering.

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			New method to deliver an immune system 'uncloaking' device directly to cancer cells Scientists at Johns Hopkins report they have designed and successfully tested an experimental, super small package able to deliver molecular signals that tag implanted human cancer cells in mice and make them visible for destruction by the animals' immune systems.

			Density of immune cells could accurately predict survival in patients with stage III colon cancer The density of immune cells, called tumor infiltrating lymphocytes, when combined with analysis of tumor budding may serve as a method to more accurately predict survival in patients with stage III colon cancer.

	Newly discovered molecule in the lymphatic system could play a role in autoimmune diseases A study by investigators at Hospital for Special Surgery has discovered a molecule in the lymphatic system that has the potential to play a role in autoimmune disease.

	Research shows how immune cells act to limit tumor development How does the immune system act to limit tumor development? Using in vivo imaging tools, scientists from the Institut Pasteur and Inserm described the spatiotemporal activity of tumor-infiltrating T lymphocytes, both locally and remotely.

	Study sheds new light on the immune system’s ability to deal with co-infection The body’s immune response to fungal infections changes when a patient is also infected by a virus, according to new research which investigated the two types of infection together for the first time.