Medical News | Medical Articles | Walking Along Chromosomes: Visualizing in situ Chromosomal Structure with Single Molecule Localization Microscopy

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Walking Along Chromosomes: Visualizing in situ Chromosomal Structure with Single Molecule Localization Microscopy Understanding chromosome structure in situ is critical in understanding normal as well as pathological functioning of the nucleus. See how single molecule localization microscopy can be used to image chromosomal regions and visualize chromosomal structure. By incorporating microfluidics and sequential labelling strategies can be employed to “walk” along chromosomes to visualize chromosome regions that form distinct structures in the form of compartments. Discover more in this free webinar Find Out More

Overcoming Issues of Scale with High Throughput Next Generation Sequencing   The diversity and volume of sequenced genomes continues to rise and the cost per megabase has continued to decrease. Researchers are now able to probe genomes to a greater depth which enables new understanding of genome sequence variants and how they underlie disease and phenotype. These advances are critical in the new discipline of personalized medicine.   Learn More         Generating genomes and encoding new abilities into artificial DNA   A new study to be presented at the American Association for the Advancement of Science (AAAS) in February 2020 will report on the generation of the world’s first artificially created bacterial genome using a digital design algorithm along with the synthesis of DNA building blocks on a large scale. This genome takes form by chemical rather than template-based synthesis.

Two genome sequences of coronavirus (COVID-19) show possible internal transmission   The coronavirus disease (COVID-19) is rapidly spreading around the globe. With the high infection rate and spread of the virus to more than 80 countries, scientists are racing to study the nature of the virus, in the hopes of finding new vaccines and therapeutics.       Pioneering project on genomic edition through CRISPR/Cas9 to study early embryonic development   Characterization studies of early embryonic development are limited, mainly due to the lack of samples and the obvious legal and ethical limitations.       Vapers exhibit similar chemical changes in their genome as smokers   Biologically important changes in DNA seen in smokers are also being found in people who vape, according to a new study published in the journal Epigenetics.       Bacterial DNA promotes tau protein misfolding and aggregation, study shows   Researchers from Human Microbiology Institute and Mitchell Center for Alzheimer’s disease at the University of Texas McGovern Medical School in Houston have discovered that bacterial extracellular DNA can trigger Tau protein misfolding into neurotoxic aggregates, a key process in Alzheimer’s disease pathogenesis.

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