Changed Route of Immunization Dramatically Improves Efficacy of TB Vaccine | NIH: National Institute of Allergy and Infectious Diseases

Changed Route of Immunization Dramatically Improves Efficacy of TB Vaccine | NIH: National Institute of Allergy and Infectious Diseases

Thursday, Jan. 2, 2020

Changed route of immunization dramatically improves efficacy of TB vaccine

The world’s only licensed tuberculosis (TB) vaccine was developed a century ago; it can protect infants from one form of the disease but is not very good at preventing the more common and more deadly pulmonary TB. Now, NIAID researchers and their colleagues have shown that delivering the vaccine intravenously dramatically improves its ability to protect rhesus macaques from infection following exposure to TB-causing bacteria.