Clinical Trials Update from NCI, October 2019

Clinical Trials Update from NCI, October 2019

Clinical Trials
Updates from the National Cancer Institute
Clinical Trials News
		PARP Inhibitors Show Promise as Initial Treatment for Ovarian Cancer Results from three new clinical trials suggest that treatment with PARP inhibitors might benefit women who are newly diagnosed with advanced ovarian cancer. In all three studies, the use of a PARP inhibitor, as first-line therapy, maintenance therapy, or both, substantially delayed the length of time before the women’s cancers came back or got worse.
		Analysis Shows Women with High Breast Cancer Recurrence Scores Benefit from Chemo A new analysis from the TAILORx randomized clinical trial shows that women with early-stage breast cancer and high recurrence scores on the Oncotype DX test who received chemotherapy with hormone therapy had better long-term outcomes than what would be expected from hormone therapy alone.
		Selpercatinib Shows Promise against Lung Cancers with Alterations in RET Gene The investigational drug selpercatinib may benefit patients with lung cancer whose tumors have alterations in the RET gene, including fusions with other genes, according to results from a small clinical trial.
TMIST Breast Screening Study TMIST (Tomosynthesis Mammographic Imaging Screening Trial) is a randomized breast screening trial that will help researchers learn about the best ways to find breast cancer in women who have no symptoms. The study compares two types of digital mammography: 2-D and 3-D. This page explains why this trial is important, who can take part, and how to enroll.
		Metastatic Breast Cancer Survivor Shares Her Clinical Trial Story In a series of Twitter posts, NCI’s Center for Cancer Research (CCR) shares the story of Samantha Seinfeld, a metastatic breast cancer survivor who participated in a CCR first-in-human clinical trial over 10 years ago. Since then, she has remained cancer-free.
Clinical Trials Information for Patients and Caregivers
Deciding to Take Part in a Clinical Trial This page discusses things to consider when you are deciding whether to take part in a clinical trial.
Questions to Ask Your Doctor about Treatment Clinical Trials Taking part in a cancer treatment clinical trial is a big decision. This page presents a list of questions you may want to ask your doctor before deciding to participate in a clinical trial.
		Find NCI-Supported Clinical Trials Use our search form to find a clinical trial or other research study that may be right for you or a loved one.
NCI-Supported Clinical Trials That Are Recruiting Patients
Antibiotic Therapy for Rare Type of Liver Cancer This phase 2 trial will test the antibiotic drug vancomycin in patients with fibrolamellar hepatocellular carcinoma (FLC) that cannot be treated surgically. FLC is a rare liver cancer that usually grows in teens and young adults. Doctors want to see if oral vancomycin is safe at a dose higher than that given for a bacterial infection and whether it has a beneficial effect on unresectable FLC.
Stereotactic Radiosurgery for Patients with Resected Brain Metastases This phase 3 trial will compare stereotactic radiosurgery given as a single treatment versus as multiple treatments over the course of several days (i.e., fractionated stereotactic radiosurgery) in patients that have had metastatic tumors surgically removed from the brain. Doctors want to find out if fractionated stereotactic radiosurgery is better or worse for these patients than the usual approach with single fraction stereotactic radiosurgery.