CIENCIASMEDICASNEWS: Medical News | Medical Articles: Three Dimensional High-Throughput Assay Development Using Liquid Handlers and Spheroid Microplates

miércoles, 30 de octubre de 2019

Medical News | Medical Articles: Three Dimensional High-Throughput Assay Development Using Liquid Handlers and Spheroid Microplates

	October 30, 2019
	Cell Biology
	The latest cell & molecular biology news from News Medical

Three Dimensional High-Throughput Assay Development Using Liquid Handlers and Spheroid Microplates

It is becoming increasingly evident that the recapitulation of the in vivo cell environment is more advanced in 3D rather than traditional 2D methodologies. This is leading to an increase in spheroid and other 3D models being employed for drug discovery.

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Cell Counting Without Slides to Reduce Waste and Cost

Until recently, cells were counted on a reusable quartz hemocytometer. With the advent of automated cell counters, disposable slides became widespread. While they're convenient for automated systems, they introduce an ongoing cost, and single-use plastic with a significant environmental footprint.

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Confocal Reflection Microscopy for Cell Migration Studies

Cell migration occurs throughout life as a response to internal and external signals, and can as such be indicative of changes occurring in the body. Imaging this movement and what processes control it can be critical in understanding cell behavior, development, and disease.

	Human Cell Models of the Developing Cortex Research into the mechanisms of early brain development, especially that of the cortex, is important in aiding our understanding of how the brain develops so that we can also understand how neurodevelopmental and neuropsychiatric disorders occur.

	Cell death 'blocker' could speed recovery and save lives Scientists in Australia have shown that they can successfully stop the process of cell death through the use of a revolutionary new compound. This innovation carries huge implications that are likely to change the face of the future of healthcare, most notably, scientists believe they can develop this work to increase patient’s chances of survival following acute injury.

	Researchers obtain 3D structural snapshots of key regulator of cell biology Some of the greatest insights into cancer and how to treat it come when basic scientists and cancer biologists and clinicians collaborate. Such a collaborative team at the Medical University of South Carolina (MUSC) recently reported in Nature Communications that they had obtained 3D structural snapshots of the enzyme Cdc34, a key regulator of cell biology and a target for cancer therapeutics.

	New Penn Medicine study unravels the early makings of an exhausted T cell The immune system struggles to defeat cancer or chronic infections because many of the T cells that leap into action end up "exhausted," rendering them ineffective against disease. That path to exhaustion and what triggers it is a crucial one that researchers aim to better understand so they can stop or divert more T cells from heading down this path.

	New liquid-cell technology provides first 3D view of life’s processes A new liquid-cell technology allows scientists to see biological materials and systems in three dimensions under an electron microscope (EM), according to researchers at Penn State, Virginia Tech and Protochips Inc.