Research sheds light on sun-induced DNA damage and repair
It is a well known fact that the sun’s ultraviolet rays can damage the skin. Now, a new study sheds light on what happens after DNA damage occurs, and how the body initiates repair.
A team of researchers at Baylor University wanted to determine the series of events that kickstart DNA repair in humans after being exposed to the sun’s damaging rays. The breakthrough study, which was published in the journal Oxford Academic Nucleic Acids Research, reveals how sunlight-induced DNA damage is recognized by the molecular repair machinery in cells for repair.
Ultraviolet (UV) light from the sun is a common carcinogen that can damage the DNA (deoxyribonucleic acid) in the body. DNA is important because it carries genetic information and blueprints for cellular functions. When the body fails to repair the DNA, damage induced by UV light, it can lead to mutations, and eventually, cancer.
UV light poses a threat on genome integrity by triggering DNA damage, also dubbed as intra-strand crosslink damage. There are two major lesions, including the cyclobutane pyrimidine dimer (CPD), which is about 70 percent of the damage and 6-4 photoproduct (6-4PP), which constitutes 30 percent.
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